Medical and Health Science Journal
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| Volume | 6 |
| Issue | 2 |
| Online publication date | 2011-04-04 |
| Title | Cytokine investigations in organs and tissues of experimental animals under prenatal hypoxic conditions of varying severity |
| Author | Zhanar Utesheva, Natalya Kravtsova, Ludmila Dzoz, Talgat Kudaibergenov, Tatyana Kravtsova |
| Abstract | The paper presents the research results of varying severity experimental hypoxia influences on the content of cytokines (IGF-1, TNF-α, IL-1β, IL-4, IL-6, IFN-γ) in organs, tissues and cells (blood, liver, brain, uterus, adrenal glands, placenta, placental lymphocytes and macrophages) of pregnant rats. The results showed the increase of pro-inflammatory cytokines synthesis on the local and system levels during experimental hypoxia augmentation. There was found the difference between placental lymphocytes and macrophages secretion. These changes of cytokine profile leads to local deficiency of anti-inflammatory factors and indicate on development of pregnancy complications and “mother-placenta-fetus” system dysfunction. |
| References | Krukier, I., 2009. Biochemical mechanisms of cellular regulation in placenta and amniotic fluid in normal and complicated pregnancy [Biohimicheskie mehanizmi kletochnoy regulyacii v placente i okoloplodnoy srede pri fiziologicheskoy i oslozhnennoy beremennosti], in Russian, Doctoral dissertation Nazyrov, A., Israilova, M., 1990. Fetal hypoxia model. Author Certificate N4807122/14 USSR [Model gipoksii ploda. Avtorskoe svidetelstvo № 4807122/14 SSSR], in Russian Orlov, A., Markaryan, M., 2003. “Early diagnostic markers of the fetal arrested development syndrome,” Materials of plenary sessions of Gynaecologists and Obstetriciansof Russian Association [Prenatalnaya diagnostika i beremennost visokogo riska: Materiali plenumov Rossiskoy Associacii akusherov i ginekologov], in Russian, Russian Federation, Rostov-on-Don, pp.154-57 |
| Keywords | Experimental hypoxia, insulin-like growth factor (IGF-1), tumor necrosis factor (TNF-α), interleukin (IL-1β, IL-4, IL-6), interferon-γ (IFN-γ) |
| Pages | 136-140 |
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