Medical and Health Science Journal

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Volume 8
Issue 4
Online publication date 2011-07-29
Title Assessment of influence of duodenogastric reflux on course of gastroesophageal reflux disease
Author Abdujabar Akhmatkhodjaev
Abstract This article shows the role and significance of duodenogastric bile reflux in patients with gastroesophageal reflux disease. Intraesophageal and intragastric pH-metric investigations, as well as biochemical studies of gastric contents were carried out. Antacid dysfunction of the stomach as a result of hypergastrinemia is conditioned by biochemical characteristics of duodenogastric bile refluctant which contains high concentrations of toxic bile acids, trypsin, lysolecithin, as well as by high phospholipase activity of refluctant, and by the reduction of such factors of cytoprotection as sIgA and phospholipids. Duodenogastric reflux in gastroesophageal reflux disease often develops because of the presence of associated biliary and pancreatic pathologies with bacterial overgrowth syndrome.
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Keywords Gastroesophageal reflux disease, duodenogastric reflux
Pages 102-106
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