Medical and Health Science Journal
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| Volume | 8 |
| Issue | 4 |
| Online publication date | 2011-07-29 |
| Title | Assessment of influence of duodenogastric reflux on course of gastroesophageal reflux disease |
| Author | Abdujabar Akhmatkhodjaev |
| Abstract | This article shows the role and significance of duodenogastric bile reflux in patients with gastroesophageal reflux disease. Intraesophageal and intragastric pH-metric investigations, as well as biochemical studies of gastric contents were carried out. Antacid dysfunction of the stomach as a result of hypergastrinemia is conditioned by biochemical characteristics of duodenogastric bile refluctant which contains high concentrations of toxic bile acids, trypsin, lysolecithin, as well as by high phospholipase activity of refluctant, and by the reduction of such factors of cytoprotection as sIgA and phospholipids. Duodenogastric reflux in gastroesophageal reflux disease often develops because of the presence of associated biliary and pancreatic pathologies with bacterial overgrowth syndrome. |
| References | Barry, O., Connor, J., Provenzale, D., Brazer, S., et al. 2000. “Economic consideration in the treatment of gastroesophageal reflux disease: a review,” Am. J. Gastroenterol., Vol.95, pp.3356-364 Belousov, S., Muratov, S., 2005. “Gastroesophageal reflux disease and duodenogastric reflux,” [“Gastroezofageal’naya refluksnaya bolezn’ I duodenogastral’niy refluks”], in Russian, Nizhniy Novgorod Buyeverov, А., Lapina, Т., 2006. “Duodenogastroesophageal reflux as a reason for reflux-esophagitis” [Duodenogastroezofageal’niy refluks kak prichina refluks-ezofagita], [Farmateka], in Russian, No.1, pp.1-5 Kazaryan, P., Маzin, D., 1990. “The levels of phosphatidylcholine, lipid peroxidation and phospholipase activity in chronic bronchitis,” Biological Journal of Armenia [Biol. Zhurnal Armenii], in Russian, Vol.43, No.6, pp.525-27 Keyts, М., 1975. “The technique of lipidology,” [“Tehnika lipidologii”], Moscow, in Russian, pp.321 Ivanov, А.I., 1973. “The quantitative determination of bile acids using SILUFOL sheets” [Kolichestvennoye opredeleniye zhelchnyh kislot zhelchi s pomosh’yu listov SILUFOL], [Lab. Delo], in Russian, No.8, pp.504-506 Оsadchuk, M., Usik, S., Chizh, A., Lipatova, Т., 2004. “Gastroesophageal reflux disease in practice of clinician,” [Gastroezofageal’naya refluksnaya bolezn’ v praktike klinicista], in Russian, Saratov Sablin, O., Grinevich, V., Uspensky, Y., Ratnikov, V., 2002. “Functional diagnostics in gastroenterology,” Methodical supplement [Funktsional’naya diagnostika v gastroenetrologii, Uchebno-metodicheskoye posobiye], in Russian, Saints Petersburg |
| Keywords | Gastroesophageal reflux disease, duodenogastric reflux |
| Pages | 102-106 |
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