Applied Technologies and Innovations

  Previous Article | Back to Volume | Next Article
  Abstract | References | Citation | Download | Preview | Statistics
Volume 7
Issue 2
Online publication date 2012-06-21
Title Anti-aggregatory and fibrinolytic effects of time-released garlic powder tablets
Author Igor Sobenin, Irina Andrianova, Viktoriya Ionova, Vasily Karagodin, Alexander Orekhov
Abstract The double-blinded placebo-controlled randomized crossover study was performed in 29 atherosclerotic men (35 to 70 years old) suffering from cerebral atherosclerosis and chronic cerebrovascular insufficiency to elucidate the effect of time-released garlic powder tablets Allicor on platelet aggregation and serum fibrinolytic activity. It has been demonstrated that Allicor 14-days treatment significantly inhibited ADP-induced platelet aggregation by 25.4% (p<0.05) and increased plasma fibrinolytic activity by 22.4% (p<0.05). Additionally, the trend to the decrease in plasma fibrinogen level was observed. Evidence obtained from this study indicates that garlic has potential in the prevention and control of cardiovascular disorders and is beneficial when taken as a dietary supplement. We conclude that Allicor may be beneficial in protecting against cardiovascular disease as a result of inhibiting platelet aggregation and normalizing plasma fibrinolytic activity.
Ackermann, R., Mulrow, C., Ramirez, G., Gardner, C., Morbidoni, L., Lawrence, V., 2001. “Garlic shows promise for improving some cardiovascular risk factors”, Arch. Intern. Med., Vol.161, pp.813-24

Ali, M., 1995. “Mechanism by which garlic (Allium sativum) inhibits cyclooxygenase activity. Effect of raw versus boiled garlic extract on the synthesis of prostanoids”, Prostaglandins Leukot. Essent. Fatty Acids, Vol.53, pp.397-400

Ali, M., Mohammed, S., 1986. “Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits”, Prostaglandins Leukot. Med., Vol.25, pp. 139-46

Ali, M., Thomson., M., Alnaqeeb, M., Al Hassan, Khater, S., Gomes, S., 1990. “Antithrombotic activity of garlic: its inhibition of the synthesis of thromboxane-B2 during infusion of arachidonic acid and collagen in rabbits”, Prostaglandins Leukot. Essent. Fatty Acids, Vol.41, pp.95-99

Aronow, W., 1999. “Antiplatelet agents in the prevention of cardiovascular morbidity and mortality in older patients with vascular disease”, Drugs Aging, Vol.15, pp.91-101

Astrup, T., Nissen, U., Rasmussen, J., 1966. “Effects of preparations of heparin and heparitin sulfate on fibrinolysis”, Arch. Biochem. Biophys., Vol.113, pp.634-40

Auer, W., Eiber, A., Hertkorn, E., 1990. “Hypertension and hyperlipidaemia: garlic helps in mild cases”, Br. J. Clin. Pract. Suppl., Vol.69, pp.3-6

Berthold, H., Sudhop, T., 1998. “Garlic preparations for prevention of atherosclerosis”, Curr. Opin. Lipidol., Vol.9, pp.565-69

Bidwell, E., 1953. “Fibrinolysis of human plasma”, Biochem. J. Vol.55, pp.497-98

Bordia, A., 1981. “Effect of garlic on blood lipids in patients with coronary heart disease”, Am. J. Clin. Nutr., Vol. 34, pp.2100-103

Bordia, A., Verma, S., Srivastava, K., 1998. “Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease”, Prostaglandins Leukot. Essent. Fatty Acids, Vol.58, pp.257-63

Bordia, T., Mohammed, N., Thomson, M., Ali, M., 1996. “An evaluation of garlic and onion as antithrombotic agents”, Prostaglandins Leukot. Essent. Fatty Acids, Vol.54, pp.183-86

Bordia, A., Verma, S., Srivastava, K., 1996. “Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease”, Prostaglandins Leukot. Essent. Fatty Acids, Vol. 55, pp.201-205

Breddin, H., Lippold, R., Bittner, M., Kirchmaier, C, Krzywanek, H., Michaelis, J., 1999. “Spontaneous platelet aggregation as a predictive risk factor for vascular occlusions in healthy volunteers? Results of the HAPARG Study. Haemostatic parameters as risk factors in healthy volunteers”, Atherosclerosis, Vol.144, pp.211-19

Chutani, S., Bordia, A, 1981. “The effect of fried versus raw garlic on fibrinolytic activity in man”, Atherosclerosis, Vol. 38, pp.417-21

Gabbasov, Z., Popov, E., Gavrilov, I., Pozin, E., 1989. “Platelet aggregation: the use of optical density fluctuations to study microaggregate formation in platelet suspension”, Thromb. Res., Vol. 54, pp.215-23

Easton, J., 1991. “Antiplatelet therapy in the prevention of stroke”, Drugs, Vol.42, Suppl.5, pp.39-50

Harenberg, J., Giese, C., Zimmermann, R, 1988. “Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia”, Atherosclerosis, Vol.74, pp.247-49

Kiesewetter, H., Jung, F., Mrowietz, C., 1990. “Effects of garlic on blood fluidity and fibrinolytic activity: a randomised, placebo-controlled, double-blind study”, Br. J. Clin. Pract. Suppl., Vol.69, pp. 24-29

Kiesewetter, H., Jung, F., Pindur, G., Jung, E., Mrowietz, C., Wenzel, E, 1991. “Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors”, Int. J. Clin. Pharmacol. Ther. Toxicol, Vol.29, pp. 151-155

Kiesewetter, H., Jung, F., Jung, E., 1993. “Effects of garlic coated tablets in peripheral arterial occlusive disease”, Clin. Investig. Vol.71, pp. 383-386

Lam, J., Latour, J., Lesperance, J., Waters, D., 1994. “Platelet aggregation, coronary artery disease progression and future coronary events”, Am. J. Cardiol., Vol.73, pp.333-38

Leys, D., 2001. “Atherothrombosis: a major health burden”, Cerebrovasc. Dis., Vol.11, Suppl. 2, pp.1-4

Luley, C., Lehmann, L., Moller, B., Martin, T., Schwartzkopff, W., 1986. “Lack of efficacy of dried garlic in patients with hyperlipoproteinemia”, Arzneimittelforschung, Vol.36, pp.766-68

Makheja, A., Bailey, J., 1990. “Antiplatelet constituents of garlic and onion”, Agents Actions, Vol.29, pp.360-63

Mohammad, S., Woodword, S., 1986. “Characterization of a potent inhibitor of platelet aggregation and release reaction isolated allium sativum (garlic)”, Thromb. Res., Vol.44, pp.793-806

Rahman, K., Billington, D., 2000. “Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans”, J. Nutr., Vol.130, pp.2662-665

Schwartz, C., Valente, A., Sprague, E., 1993. “A modern view of atherogenesis”, Am. J. Cardiol., Vol.71, pp.9B-14B

Steele, P., Weily, H., Davies, H., Genton, E., 1973. “Platelet function studies in coronary artery disease”, Circulation, Vol.48, pp.1194-1200

Srivastava, K., 1986. “Evidence for the mechanism by which garlic inhibits platelet aggregation”, Prostaglandins Leukot. Med., Vol.22, pp.313-21

Steiner, M., Li, W., 2001. “Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions”, J. Nutr., Vol.131, pp.980S-984S

Verhaeghe, R., 1991. “Prophylactic antiplatelet therapy in peripheral arterial disease”, Drugs, Vol.42, Suppl. 5, pp.51-57

Keywords Platelet aggregation, fibrinolysis, atherosclerosis, garlic, Allicor
Pages 40-45
Download Full PDF Download
  Previous Article | Back to Volume | Next Article
Search in articles
Journal Published articles
ATI 263
Journal Hits
ATI 767151
Journal Downloads
ATI 7688
Total users online -