Europhysics Letters
| Previous Article | Back to Volume | Next Article | |
| Abstract | References | Citation | Download | Preview | Statistics | |
| Sample volume | 1 |
| Title | Quantised transistor response to ion channels revealed by nonstationary noise analysis |
| Author | C. Becker-Freyseng, P. Fromherz |
| Abstract | We report on the quantised response of a field-effect transistor to molecular ion channels in a biomembrane. HEK293-type cells overexpressing the Shaker B potassium channel were cultured on a silicon chip. An enhanced noise of the transistor is observed when the ion channels are activated. The analysis of the fluctuations in terms of binomial statistics identifies voltage quanta of about 1 μV on the gate. They are attributed to the channel currents that affect the gate voltage according to the Green's function of the cell-chip junction. |
| Citation | |
| References | [1] Prost J. and Bruinsma R., Europhys. Lett., 33 (1996)321. [2] Ries J., Petrov E. P. and Schwille P., Biophys. J., 95 (2008) 390. [3] Hilt M. and Zimmermann W., Phys. Rev. E, 75 (2007) 016202. [4] Medalia O. and Geiger B., Curr. Opin. Cell Biol., 22 (2010) 659. [5] Giaever I. and Keese C. R., Proc. Natl. Acad. Sci. U.S.A., 88 (1991) 7896. [6] Domanska M. K., Kiessling V. and Tamm L. K., Biophys. J., 99 (2010) 2936. [7] Fromherz P., Solid-State Electron., 52 (2008) 1364. [8] Katz B. and Miledi R., J. Physiol. (London), 224 (1972) 665. [9] Neher E. and Sakmann B., Nature, 260 (1976) 799. [10] Sigworth F. J., Nature, 270 (1977) 265. [11] Weis R. and Fromherz P., Phys. Rev. E, 55 (1997) 877. [12] Schatzthauer R. ¨ and Fromherz P., Eur. J. Neurosci., 10 (1998) 1956. [13] Straub B., Meyer E. and Fromherz P., Nat. Biotechnol., 19 (2001) 121. [14] Brittinger M. and Fromherz P., Appl. Phys. A, 81 (2005) 439. [15] Peitz I. and Fromherz P., Eur. Phys. E, 30 (2009) 223. [16] Voelker M. and Fromherz P., Phys. Rev. Lett., 96 (2006) 228102. [17] Hoshi T., Zagotta W. and Aldrich R., Science, 250 (1990) 533. [18] Lopez-Barneo J., Hoshi T., Heinemann S. H. ´ and Aldrich R. W., Recept. Channels, 1 (1993) 61. [19] Starkus J. G., Varga Z., Schonherr R. ¨ and Heinemann S. H., Eur. J. Physiol., 447 (2003) 44. [20] Sigworth F. J., Biophys. J., 35 (1981) 289. [21] Heinemann S. H. and Conti F., Methods Enzymol., 207 (1992) 131. [22] Steffan R. and Heinemann S. H., J. Neurosci. Methods, 78 (1997) 51. [23] Voelker M. and Fromherz P., Small, 1 (2005) 206. [24] Hutzler M. and Fromherz P., Eur. J. Neurosci., 19 (2004) 2231. [25] Wallrapp F. and Fromherz P., J. Appl. Phys., 99 (2006) 114103. [26] Stein W. et al., Sage Mathematics Software (Version 4.1), The Sage Development Team, http://www.sagemath.org (2009). [27] Iverson L. E., Tanouye M. A., Lester H. A., Davidson N. and Rudy B., Proc. Natl. Acad. Sci. U.S.A., 85 (1988) 5723. [28] Heginbotham L. and MacKinnon R., Biophys. J., 65 (1993) 2089. [29] Haberman R., Applied Partial Differential Equations, 4th edition (Pearson Education, Upper Saddle River, NJ) 2004, p. 432. |
| Keywords | |
| Download Full PDF | Download |
| Previous Article | Back to Volume | Next Article |
| Share |