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Volume 10
Issue 1
Online publication date 2012-03-22
Title The level of mediators of immune response in infants with congenital cleft lip and palate
Author Amrillo Inoyatov, Mamur Abdurakhmanov, Sanjar Sharopov, Mukhamajon Azimov
Abstract 57 infants were examined at age from 0 to 15 months with congenital clefts. Operative-medical actions were conducted after the checkup of infant depending on degree of deformation. 16 practically sound infants of the similar age formed the control group. Study of cytokine levels for IL-1, TNF, IFNγ in blood serum was made using IFA method. Received results showed that increasing level of pro-inflammatory cytokines was observed under congenital cleft. Depth of broken level depends on clinical form of congenital clefts. The most deflection was observed on infants with congenital double-sided cleft lip and palate (CCLP-2). The noted changes on condition of cytokine status on infants with congenital cleft lip and palate led to qualifying the secondary immunodeficient condition, requiring undertaking immunomodulating actions.
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Keywords Cleft lip and palate, immunity, cytokines
Pages 30-36
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