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Volume 10
Issue 1
Online publication date 2012-03-22
Title Enzymatic activity of the intestine in effect of pesticides of pyrethroid group
Author Mukaddas Khamrakulova
Abstract
The purpose of investigation was to study the effect of pesticides from group of pyrethroids (e.g. decis) on the enzymatic function in the homogenate of the mucosal membrane of the proximal and distal segments of the small intestine.
Determination of the degree of the activity of hydrolytic enzymes in the homogenates of some parts of the intestine allowed to show effect of pesticide decis on the gradient of distribution of enzymatic activity along the intestine. For characteristic of the enzymatic activity of the small intestine there was performed study of the activity of dipeptidase, amylase, invertase and alkaline phosphatase in the homogenate of the mucosal membrane from proximal and distal parts in multiple effects of pesticide decis in toxic dose (1/20 LD50 ) during 4 months.
Changes of the enzymatic activity in acute poisoning were depended on the time of pesticide exposure and site of the bowel. The different digestive enzymes have different response to effect ofpesticidesof pyrethroid group (decis), there are differences in the reactions of proximal and distal part of the small intestine and there is correlation between changes of activity of the majority hydrolases and administered dose of pesticides.

Citation
References
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Gera, N., Kiran, R., Mahmood, A., 2009. “Subacute effects of carbofuran on enzyme functions in rat small intestine,” Toxicol Mech. Methods, Vol.19(2), pp.141-47

Labana, S., Bansal, R., Mahmood, A., 2001a. “Age related effects of organochlorine insecticide lindane on intestinal brushborder membrane in rats,” Indian J Biochem. Biophys., Vol.38(4), pp.249-52 

Labana, S., Bansal, R., Mahmood, A., 2001b. “Effects of endosulfan on intestinal functions in protein-malnourished rats,” Indian J Exp. Biol., Vol.39(10), pp.1017-1021

Timofeeva, N., Iezuitov, N., Makulina, G., 1971. Membrane digestion and transport in single and repeated effects of some stress factors, in: Physiology and pathology of the digestive organs [Fiziologija i patologija organov pishhevarenija], in Russian, I All-Union conf. on physiology and pathology of digestion, Moscow

Ugolev, A.M.,1969. Determination of amylolitic activity’, in: ‘Study of the human digestive apparatus [Opredelenie amiloliticheskoj aktivnosti. Issledovanie pishhevaritel'nogo apparata u cheloveka], in Russian, Leningrad: Nauka

Ugolev, A., Iezuitova, N., 1969. Determination of the activity of invertase and other disaccharides”, in: ‘Study of the human digestive  apparatus [Opredelenie amiloliticheskoj aktivnosti. Issledovanie pishhevaritel'nogo apparata u cheloveka], in Russian, Leningrad: Nauka

Ugolev, A., Timofeeva, N., 1969. “Determination of the proteolitic activity,” In: Ugolev, A., Iuzeitova, A., Masevich, N. et al. (Eds.), .Study of the human digestive  apparatus [Opredelenie proteoliticheskoj aktivnosti. Issledovanie pishhevaritel'nogo apparata u cheloveka], in Russian, pp.176-178

Keywords Small intestine, enzymes activity, dipeptidase, amylase, invertase, alkaline phosphatase, pesticide Decis
Pages 62-66
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