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Volume 13
Issue 4
Online publication date 2012-12-15
Title Fluctuations of CD34 cells number in blood of cancer patients during final year of life
Author Alexey Shoutko, Lyudmila Ekimova, Viktor Mus, Valentina Sokurenko
Abstract
The purpose of the work was the comparative study of dynamic relations between the fluctuation of survival rate and presence of hematopoietic progenitor cells in circulating blood of oncologic patients in the final months of their life. The registered associativity turbulence in the content of CD34 cells in a blood of the advanced oncologic patients and turbulence of probability of their death leads to the assumption that the reason for life’s cessation may be the abnormal morphogenic activity of young cells produced in the bone marrow toward the tumor tissues of the host,  as well as a lack of such activity toward the critical normal tissues. Thus, the cytotoxic, especially long-term, therapy of patients with advanced cancer may be timely even harmful for them and compromise the ultimate result of treatment.
The regimes of cytotoxic therapy of patients in cases of premature exhaustion of haematopoietic resource should be optimized based on individual periodicity of blood saturation with progenitor cells. The development of reliable and simple methods for  clinical monitoring of quickly changing prognosis of patients status  seems to become important aim of coming investigation. The data might be useful for optimization of regimes of cytotoxic therapy of individual patients in emergency.
Citation
References
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Keywords Cancer, survival, life span, monthly risk of a mortality, periodicity, blood stem cells, approximation
DOI http://dx.doi.org/10.15208/mhsj.2012.52
Pages 7-13
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