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Volume 13
Issue 4
Online publication date 2012-12-15
Title Effect of prolonged exposure of low doses of lambda-cyhalothrin on the thyroid function of the pregnant rats and their offspring
Author Kadir Tukhtaev, Nargiza Zokirova, Sabirjan Tulemetov, Nodirbek Tukhtaev
Abstract Lambda-cyhalothrin (LCT) is widely used pyrethroid insecticide for pest control in agriculture, health, home and garden. We studied the effects of prolonged exposure to low doses of LCT on the state of thyroid hormones (TH): thyroxine (T4), triiodothyronine (T3), and thyroid -stimulating hormone (TSH) of the pregnant rats and their offspring. Prior to pregnancy in female rats, effects of LCT for 30 days resulted in only a slight decrease in TH levels, but it significantly increased the concentration of TSH. In contrast, the impact of LCT in pregnant, and especially in lactating rats, and also their offspring have led to a marked reduction in TH levels with a significant increase in TSH levels. Thus, the LCT has a fairly pronounced thyroid - disrupting effects in the pregnant rats, and its impact creates a risk for further growth and development of the offspring.
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Keywords Lambda-cyhalothrin, thyroid hormones, pregnancy, offspring
Pages 86-92
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