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Volume 13
Issue 4
Online publication date 2012-12-15
Title Effect of long term exposure of low doses of lambda- cyhalothrin on the level of lipid peroxidation and antioxidant enzymes of the pregnant rats and their offspring
Author Kadir Tukhtaev, Sabirjan Tulemetov, Nargiza Zokirova, Nodirbek Tukhtaev
Abstract Lambda- cyhalothrin (LCT) is a pyrethroid insecticide class, which is widely used for pest control in agriculture, public health, home and garden. In the present study we investigated the effect of long term exposure of low doses of the LCT on the state of lipid peroxidation and antioxidant protection of pregnant rats and their offspring. It was revealed, that prolonged exposure of lambda-cyhalothrin leads to the development of oxidative stress in both of pregnant females and their offspring. The highest level of lipid peroxidation detected on 14-21 days of pregnancy, which was accompanied by a reduction in activity of antioxidant enzymes. In the offspring highest level of oxidative stress observed on 7-14 days of lactation. The degree of oxidative stress in offspring decreases as the cessation of receipt of a pesticide or its toxic metabolites in breast milk.
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Keywords Oxidative stress; lambda-cyhalotrin; pregnancy; developmental toxicity
Pages 93-98
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