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Volume 13
Issue 4
Online publication date 2012-12-15
Title Preventive activity of ascorbic acid on lead acetate induced cerebellar damaged in adult Wistar rats
Author Sunday Abraham Musa, Iliyasu, Musa Omoniye, Wilson Oliver Hamman, Augustine Oseloka Ibegbu, Uduak Emmanuel Umana
Abstract
Among the environmental contaminants, lead is one of the most hazardous to living matter. In mammals, the main target is the central nervous system, particularly in the young. Ascorbic acid is an antioxidant which is a substance that may protect your cells against the effects of free radicals. 
This study investigated Experiment the protective effect of ascorbic acid on the cerebellum of adult Wistar rats following oral administration of different doses of Lead acetate. Thirty adult Wistar rats of average weight of 215g were used in this study. The animals were divided into five (5) groups of six animals per group and were administered different doses of lead acetate (60mg/kg bwt of 1/10th LD50 and 30mg/kg bwt of 1/20th of LD50) and ascorbic acid (4.3mg/kg bwt) orally over a period of three (3) weeks.
Group 1 (control) was administered distilled water and Group 2 and 3 were administered 30mg/kg and 60mg/kg of Lead acetate respectively while Group 4 and 5 were given co-administration of 30mg/kg of Lead acetate 4.3mg/kg of ascorbic acid and 60gm/kg of Lead acetate 4.3mg/kg of ascorbic acid respectively. Histopathologically, Lead acetate induced cellular damage in the cerebellum of adult Wistar rats and it was also observed that ascorbic acid prevents or minimize lead-induced  cellular damage in the cerebellum of adult Wistar rats.

Citation
References
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Keywords Lead acetate, ascorbic acid, cellular, cerebellar damage
DOI http://dx.doi.org/10.15208/mhsj.2012.68
Pages 99-104
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