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Volume 14
Issue 1
Online publication date 2013-04-25
Title Analysis of CTLA-4 gene 49A/G polymorphism in patients with Chronic Hepatitis C in Uzbekistan
Author Sevara Azimova, Khamid Karimov, K. Boboev
Abstract HCV has a high capacity for persistence and causes chronic hepatitis with an increased risk of development of liver cirrhosis. Immunological response of the body has the unique role, since it not only eliminates the virus, but also causes damage of liver cells. Immune status is first conditioned by genetic factors, so immunogenetic aspects determine the features of development and progression of viral hepatitis with transition to liver cirrhosis. The article deals with the analysis of association of CTLA-4 (cytotoxic T-lymphocyte associated antigen-4) gene 49A/G polymorphism with development of liver cirrhosis in patients with chronic hepatitis C.
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Keywords Hepatitis C, liver cirrhosis, immunogenetics, CTLA-4 gene 49A/G polymorphism
Pages 17-23
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