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Volume 14
Issue 2
Online publication date 2013-04-25
Title Investigations of rheological properties of diclofenac sodium gel preparation
Author Firuza Maksudova, Ekut Karieva
It is well-known that the majority of non-steroidal anti-inflammatory drugs (NSAIDs) are ulcerogenic. Gel or ointment preparations of NSAIDs are free from this side-effect, which is a prerequisite for the increase of aforementioned forms of NSAIDs. A major quality indicator of gels and ointments are rheological properties. Along with determining the quality of preparation, they influence manufacturing, expiration date and terms of storage.
This article demonstrates the results of investigation of rheological indices of 3% gel preparation of diclofenac sodium such as plasticity, structural viscosity, and thixotropy.
Obtained results confirm that the developed gel preparation has thixotropy, plasticity and is classified as a Bingham system.
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Keywords Diclofenac sodium, rheological properties of gel, thixotropy, dynamic viscosity, hysteresis loops
Pages 91-94
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