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Volume 14
Issue 2
Online publication date 2013-04-25
Title Investigations of rheological properties of diclofenac sodium gel preparation
Author Firuza Maksudova, Ekut Karieva
Abstract
It is well-known that the majority of non-steroidal anti-inflammatory drugs (NSAIDs) are ulcerogenic. Gel or ointment preparations of NSAIDs are free from this side-effect, which is a prerequisite for the increase of aforementioned forms of NSAIDs. A major quality indicator of gels and ointments are rheological properties. Along with determining the quality of preparation, they influence manufacturing, expiration date and terms of storage.
This article demonstrates the results of investigation of rheological indices of 3% gel preparation of diclofenac sodium such as plasticity, structural viscosity, and thixotropy.
Obtained results confirm that the developed gel preparation has thixotropy, plasticity and is classified as a Bingham system.
Citation
References
Ahmetova, T., Egorova, S., 2008. “Argumentation of optimum of rheological parameters of ocular gel preparations,” Pharmacy [Pharmacia], in Russian, No.4, pp.43-45

Bolshakova, L., Litvinova, E., Zhmurina, N., Burceva, E., 2012. “Influence of various technological factors on rheological characteristics of alginate gels,” Contemporary scientific and educational problems [Sovremennye problemy nauki i obrazovaniya], in Russian, No.6, pp.33-37

Chawla, V., Saraf, S., 2012. “Rheological studies on solid lipid nanoparticle based carbopol gels of aceclofenac,” Colloids and Surfaces B: Biointerfaces, Vol.92, pp.293-98

Lyapunov, N., Volovik, N., 2001. “Investigation of rheological properties of gels formed by carbomers ,”  Pharmakom [Farmakom], in Russian, No.2, pp.52-61

Malkin, A., 2007. Rheology: Concepts, methods, supplements [Reologiya: Koncepcii, metody, prilozheniya], in Russian, St Petersburg: Professiya 

Moreira, T., Pereira de Sousa, V., Pierre, M., 2010. “Influence of leic acid on the rheology and in vitro release of lumiracoxib from poloxamer gels,” J. Pharm Pharmaceut Sci, Vol.13(2), pp.121-38

Percev, I., Gutorov, S., Haleyeva, E., 2002. “Quality control and manufacturing of soft preparations in light of requirements of National Pharmacopea of Ukraine,” Pharmacist [Provizor], in Russian, No.8, pp. 29-31

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Keywords Diclofenac sodium, rheological properties of gel, thixotropy, dynamic viscosity, hysteresis loops
DOI http://dx.doi.org/10.15208/mhsj.2013.15
Pages 91-94
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