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Volume 14
Issue 2
Online publication date 2013-04-25
Title Pharmacogenetic efficacy of perindopril in children and adolescents with type 1 diabetes mellitus in prediction of diabetic nephropathy
Author Gulnara Rakhimova, Akida Sadykova, Nasiba Alimova
DD genotype of ACE gene is a predisposing factor for chronic kidney disease terminating nephrotic syndrome in children with type 1 diabetes mellitus, while ACE gene II genotype upon diabetic nephropathy appears to be a protective one. The work was initiated to assess efficacy of perindopril in normoalbuminuric patients with type 1 diabetes mellitus by ACE genotype in the primary intervention of diabetic nephropathy. 22 normoalbuminuric patients with type 1 diabetes mellitus aged from 12 to 70 with diabetic nephropathy duration of 10 and more years were examined to be divided into two groups by ACE polymorphism including eleven-by-eleven carriers of II genotype and DD genotype, respectively. Perindopril in low doses is recommended to treat normoalbuminuric children and adolescents for optimization of intervention and therapy of diabetic nephropathy.
Akhrarkhodzhaeva, N., 2005. Clinical diagnostic value of urinary neutral alpha-glucosidase in diabetes mellitus [Kliniko-diagnosticheskoe znachenie opredeleniya aktivnosti neytralnoy alfa-glukozidazy mochi pri sakharnom diabete], in Russian, Synopsis of doctoral dissertation, Tashkent

Amann, B., Tinzmann, R., Angelkort, B., 2003. “ACE inhibitors improve diabetic nephropathy though suppression of renal MCP-1,” Diabetes Care, Vol.6(8), pp.2421-425

Arfa, I., Abid, A., Nouira, S., Elloumi-Zghal, H., Malouche, D. et al., 2008. “Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients,” J Renin Angiotensin Aldosterone Syst., Vol.9(1), pp.32-36

Azar, S., Zalloua, P., Medlej, R., Halabi, G., 2001. “The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in the type 1 diabetics,” Endocr Res., Vol.27(1-2), pp.99-108

Bondar, I., Pupyshev, A., Klimontov, V., 2000. “Activity of lysosomal blood serum and blood leukocytes on patients with type 1 diabetes mellitus,” Problems of endocrinology [Problemy endokrinologii], in Russian, No.5, pp.3-6

Boright, A., Paterson, A., Mirea, L., Bull, S., Mowjoodi, A., Scherer, S., Zinman, B., 2005. “Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: The DCCT/EDIC Genetics Study,” Diabetes, Vol.54, pp.1238-244

Böger, C., Götz, A., Krüger, B., Hösl, M., Schmitz, G., 2005, “Effect of genetic variation on therapy with angiotensin converting enzyme inhibitors or angiotensin receptor blockers in dialysis patients,” Eur J Med Res., Vol.10(4), pp.161-68

Lebedeva, M., Balkarov, I., Lukicheva, T., 1998. “Clinical and diagnostic value of determination of microalbuminuria and activity of N-acetyl-beta-glycosaminidase, tubular enzyme, in persons with hyperuricosuria,” Therapeutic archive [Terapevticheskiy arhiv], in Russian, No.4, pp.48-54

Luther, Y., Bantis, C., Ivens, K., Kolb-Bachofen, V., Heering, P., 2003. “Effects of genetic polymorphisms of the renin-angiotensin system on focal segmental glomeruosclerosis,” Kidney Blood Press Res., Vol.26(5-6), pp.333-37

National High Blood Pressure Education Program, Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents, 2004. Pediatrics, Vol.114, pp.555-76

Ng, D., Tai, B., Koh, D., Chia, K., 2005. “Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: A meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects,” Diabetologia, Vol.48(5), pp.1008-1016

Ortega-Pierres, L., Gómez Garcia, A., Rodrigues-Ayala, E., 2007. “Angiotensin-1 converting enzyme insertion/deletion gene polymorphism in a Mexican population with diabetic nephropathy,” Med Clin (Barc), Vol.129(1), pp.6-10

Penno, G., Chatuvedi, N., Talmud, P., Cotroneo, O., Manto, A., Nannipieri, M., Luong, L., Fuller, J. and the EUCLID Study Group, 1988. “Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: Findings from the EUCLID Randomized Controlled Trial of Lisinopril in IDDM,” Diabetes, Vol.47, pp.1507-511

Rakhimova, G., Mukhamedov, R., Nurmatov, Sh., 2007. “Association of ACE gene I/D polymorphic markers with onset and progression of diabetic nephropathy in Uzbek children and adolescents,” Problems of biology and medicine [Problemy biologii i mediciny], in Russian, No.1, pp.86-88

Rakhimova, G., Sadykova, A., 2009. “Novel clinical-genetic risk factors for onset and progression of chronic kidney disease in Uzbek children and adolescents with type 1 diabetes mellitus,” International Journal of Endocrinology [Mezhdunarodnyj endokrinologicheskiy zhurnal], in Russian, No.4(22), pp.28-33

Ruggenenti, P., Bettinaglio, P., Pinares, F., Remuzzi, G., 2008. “Angiotensin converting enzyme insertion/deletion polymorphism and renoprotection in diabetic and nondiabetic nepropathies,” Clin J Am Soc Nephrol, Vol.3(5), pp.1511-525

Shamansurova, Z., Akhrarkhodzhaeva, N., Akbarov, Z., Kasymov, U., 2004. Significance of enzymuria in early diagnosis of diabetic nephropathy [Znachenie fermenturii v ranney diagnostike diabeticheskoy nefropatii], in Russian, Guidelines, Uzbekistan, Tashkent: “KhT Mamasaidov” Publishing House

Sharnova, J., Tsygin, A., Tikhomirov, E., 2006. “Polymorphism of rennin-angiotensin-aldosterone system genes upon nephrotic syndrome in children,” Nephrology and dialysis  [Nefrologiya i dializ], in Russian, Vol.8(3), pp.22-26

Shestakova, M., Nosikov, V., Vikulova, O., 2007. Predicting diabetic nephropathy in patients with type 1 diabetes mellitus on the basis of molecular-genetic studies [Opredelenie prognoza razvitiya diaebticheskoy nefropatii u bolnykh sakharnym diabetom tipa 1 na osnove molekulyarno-geneticheskikh issledovaniy], in Russian,  Guidelines for physicians, Moscow

Tsygin, A., Pinelis, V., Tikhomirov, E., 2005. “Impact of ACE I/D gene polymorphism on the progression of nephrotic syndrome in children,” Pediatric Nephrology [Detskaya nefrologiya], in Russian, Vol.20, pp.86

Keywords Alpha-glucosidase, angiotensin converting enzyme, diabetic nephropathy, polymorphism
Pages 95-100
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