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Volume 14
Issue 3
Online publication date 2013-11-14
Title Immunologic and immunobiochemical features of uveitis at Vogt-Koyanagi-Harada syndrome
Author Kh. Kamilov, D. Fayzieva, N. Akhmadaliev
Abstract The purpose of our research is to study immunologic and immunobiochemical indicators at patients with VKH syndrome. 35 pairs of eyes (21 patients aged from 16-42 years) with Vogt-Kayanagi-Harada (VKH) syndrome and 13 almost healthy faces were surveyed. At all patients along with the standard ophthalmologic inspections there were investigated immunologic and immunobiochemical indicators of a peripheral blood. The uveitis at a syndrome of VKH is characterized by the changes of cellular immunity which were more expressed at an excavation and complication of inflammatory process. The significant role in a uveitis pathogenesis at a syndrome of VKH is played by autoimmune process that proves accumulation in blood serum of excess concentration of circulating immune complexes and immunoglobulins of classes G and M. Studying of immune mechanisms of a uveitis at VKH syndrome opens new opportunities for well-timed diagnostics and pathogenetically focused therapy of this disease.
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Sugita, S., Takase, H., Taguchi, C. et al., 2006. "Ocular infiltrating CD4 T cells from patients with VKH disease recognize human melanocyte antigens," Invest. Ophthalmol. Vis. Sci., Vol.47, pp.2547-554.
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Yun, S.L., Ahjoku, A.O., Cheng-Rong, Y., Charles, E., 2011. "Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10," Immunology, Vol.132, pp.492-502.
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Keywords Vogt-Koyanagi-Harada syndrome, immunologic and immunobiochemical indicators
Pages 118-122
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