Medical and Health Science Journal
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| Volume | 14 |
| Issue | 3 |
| Online publication date | 2013-11-14 |
| Title | Polymorphism of interleukin-1β gene and susceptibility to chronic adenoiditis development at children of Siberia |
| Author | Natalia Terskova, Natalia Shnayder, Sergey Vakhrushev |
| Abstract | The research objective was to establish a role of polymorphism of interleukin-1β gene in the locus 3954 (rs 1143634) on the chromosome 2q13-21 as a risk factor of an adverse course of the inflammatory process at chronic adenoiditis. The research is a part of the complex scientific subject "Translational Otorhinolaryngology" which was carried out in 2010-2012. The results of genotyping of 944 people were received. High total frequency of inheritance of mutant polymorphic allelic variants of interleukin-1β gene, including homozygous (C/C) and heterozygous (С/Т) carriage is revealed at children with chronic adenoiditis. The frequency was 95,5% in sampling. At a homozygous carriage of oligonucleotide replacement of thymine for cytosine in the position 3954 of interleukin-1β gene functional activity of interleukin-1β changed- its pro-inflammatory effect increased by 100%. Children of this group had a heavy current chronic adenoiditis with the frequent aggravations, complications and the interfacing diseases at high concentration in blood serum interleukin-1β (298,4±8,2) pg/ml (control − 65,43 pg/ml) (p˂0,001). |
| Citation | |
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| Keywords | Chronic adenoiditis, Gene polymorphism, Interleukin-1β |
| DOI | http://dx.doi.org/10.15208/mhsj.2013.26 |
| Pages | 150-159 |
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