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Volume 14
Issue 3
Online publication date 2013-11-14
Title Polymorphism of interleukin-1β gene and susceptibility to chronic adenoiditis development at children of Siberia
Author Natalia Terskova, Natalia Shnayder, Sergey Vakhrushev
Abstract The research objective was to establish a role of polymorphism of interleukin-1β gene in the locus 3954 (rs 1143634) on the chromosome 2q13-21 as a risk factor of an adverse course of the inflammatory process at chronic adenoiditis. The research is a part of the complex scientific subject "Translational Otorhinolaryngology" which was carried out in 2010-2012. The results of genotyping of 944 people were received. High total frequency of inheritance of mutant polymorphic allelic variants of interleukin-1β gene, including homozygous (C/C) and heterozygous (С/Т) carriage is revealed at children with chronic adenoiditis. The frequency was 95,5% in sampling. At a homozygous carriage of oligonucleotide replacement of thymine for cytosine in the position 3954 of interleukin-1β gene functional activity of interleukin-1β changed- its pro-inflammatory effect increased by 100%. Children of this group had a heavy current chronic adenoiditis with the frequent aggravations, complications and the interfacing diseases at high concentration in blood serum interleukin-1β (298,4±8,2) pg/ml (control − 65,43 pg/ml) (p˂0,001).  
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Keywords Chronic adenoiditis, Gene polymorphism, Interleukin-1β
Pages 150-159
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