Medical and Health Science Journal
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| Volume | 14 |
| Issue | 4 |
| Online publication date | 2013-12-25 |
| Title | Oncological principles in the surgical treatment of primary retroperitoneal soft tissue sarcomas |
| Author | Damyan Damyanov, Y. Asenov, P. Kurtev, Boyko Koroukov, N. Penkov, P. Gerzilov |
| Abstract | Retroperitoneal tumors are uncommon neoplasms which account approximately 15% of all soft tissue sarcomas. The aim of the study is to define the optimal principles in the surgical treatment of primary retroperitoneal soft tissue sarcomas. Material and methods: The present study includes 84 patients with retroperitoneal soft tissue sarcomas hospitalized and operated in Universal Hospital “Queen Joanna” and Specialized Hospital for Active Treatment in Oncology - Sofia between 2001- 2012. We assessed several factors – patients’ demographics, tumor characteristics, type of treatment and treatment related outcome, 3- and 5-years survival. All data was analyzed with SPSS 19 (Kaplan-Maier methods, Cox- regression and the long-rank test, univariate analysis and comparison of studied variables). Results: In our study the median age was 55 years and 7 months. Radical surgery was carried out in 60.7 % (51 patients) and combined resection of organs and/or blood vessels was needed in 35,7% (30 patients). Explorative laparotomies with biopsy or partial resections were performed in 39,3%. The goal of surgical resection was negative macroscopic margins and the adjacent organs were resected only in cases with certain infiltration. Metastases were detected in ~20% (17 patients) of the cases. Type of the operation is an important prognostic factor of survival. 3-year and 5-year survival rates were 48,2% and 36,6% in patients with retroperitoneal sarcoma. Conclusion: Surgical treatment is the only opportunity for cure to the patients with retroperitoneal sarcomas. Radical resection with macroscopically negative margins is an important prognostic factor. |
| Citation | |
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| Keywords | Retroperitoneal; soft-tissue sarcomas; retroperitoneal sarcomas; surgical treatmen; prognostic factor |
| DOI | http://dx.doi.org/10.15208/mhsj.2013.28 |
| Pages | 166-173 |
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