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Volume 14
Issue 4
Online publication date 2013-12-25
Title Oncological principles in the surgical treatment of primary retroperitoneal soft tissue sarcomas
Author Damyan Damyanov, Y. Asenov, P. Kurtev, Boyko Koroukov, N. Penkov, P. Gerzilov
Retroperitoneal tumors are uncommon neoplasms which account approximately 15% of all soft tissue sarcomas. 
The aim of the study is to define the optimal principles in the surgical treatment of primary retroperitoneal soft tissue sarcomas. Material and methods: The present study includes 84 patients with retroperitoneal soft tissue sarcomas hospitalized and operated in Universal Hospital “Queen Joanna” and Specialized Hospital for Active Treatment in Oncology - Sofia between 2001- 2012. We assessed several factors – patients’ demographics, tumor characteristics, type of treatment and treatment related outcome, 3- and 5-years survival. All data was analyzed with SPSS 19 (Kaplan-Maier methods, Cox- regression and the long-rank test, univariate analysis and comparison of studied variables). Results: In our study the median age was 55 years and 7 months. Radical surgery was carried out in 60.7 % (51 patients) and combined resection of organs and/or blood vessels was needed in 35,7% (30 patients). Explorative laparotomies with biopsy or partial resections were performed in 39,3%. The goal of surgical resection was negative macroscopic margins and the adjacent organs were resected only in cases with certain infiltration. Metastases were detected in ~20% (17 patients)  of the cases. Type of the operation is an important prognostic factor of survival. 3-year and 5-year survival rates were 48,2% and 36,6% in patients with retroperitoneal sarcoma. Conclusion: Surgical treatment is the only opportunity for cure to the patients with retroperitoneal sarcomas. Radical resection with macroscopically negative margins is an important prognostic factor.

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Keywords Retroperitoneal; soft-tissue sarcomas; retroperitoneal sarcomas; surgical treatmen; prognostic factor
Pages 166-173
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