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Volume 15
Issue 1
Online publication date 2014-03-12
Title Influence of human recombinant interleukin-1beta on protective and immunogenic efficacy of live plague vaccine
Author Pavel Deryabin, Tatayana Ponomaryova, Boris Karalnik, T. Tugambayev, Tatyana Denisova, B. Atshabar, S. Zakaryan, N. Melnikova
Abstract Vaccination against plague is an important element of control over this exceptionally virulent infection. To be effective against virulent Yersinia pestis strains live plague vaccine produced from Yersinia pestis EV strain (EV vaccine) requires annual revaccinations. Use of EV vaccine for revaccination is limited due to the initially developed immune response that suppresses the live vaccine culture. Earlier studies showed that the use of immunomodulators activates immune response to vaccination. In our study we assessed the influence of human recombinant interleukin-1beta (Betaleukin) on immunogenic and protective efficacy of live plague vaccine in controlled experiments on animal models (rabbits and guinea pigs).  In a long experiment (261 days) on rabbits we assessed indicators of antigen specific immune response to F1 antigen of Yersinia pestis.  The early antigen specific response was evaluated based on the appearance of different avidity lymphocytes with F1 receptors.  Effector phase of the immune response was asses based on the activity of antigen-specific antibodies.  Results showed that the use of betaleukin as an immunoadjuvant increases vaccination efficacy by strengthening the effector phase of the immune response and promotion of the early stage of antigen-specific immune response to EV vaccine.  Protective efficacy of betaleukin and EV vaccine combination was assessed in an experiment with guinea pigs. This experiment showed that injections of betaleukin facilitates the production of antibodies following vaccination and significantly increases the rates of survival after the challenge with virulent plague strain.  At the same time single injections of betaleukin alone did not protect guinea pigs from death after injections of virulent plague strains. 
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References
Atshabar, B.B., Burdelov, L.A., Sadovskaya, V.P. et al., 2012. "Atlas of distribution of especially dangerous infections in the Republic of Kazakhstan,"Almaty, Kazakhstan
 
Baker, E.E., Sommer, H., Foster, L.E., Meyer, E., Meyer, K.F., 1952. "Studies on immunization against plague. I. The isolation and characterization of the soluble antigen of Pasteurella pestis," J Immunol., 68(2), pp.131-145
 
Bekshin, Z.M., Zhandosov, Sh.U., Shiyanov, B.N., Ivanova, R.S. et al., 2012. Sanitary and epidemiological situation and progress report of epidemiological department of the Ministry of Health. Ministry of Health of the Republican of Kazakhstan. Astana, Kazakhstan
 
Dennis, D.T., Gage, K.L., Gratz, N., Poland, J.D., and Tikhomirov, E., 1999. Plague Manual: Epidemiology, Distribution, Surveillance and Control. World Health Organization, Geneva. WHO/CDS/CRS/EDC/99.2
 
Deryabin, P.N., Karalnik, B.V., Prasolova, L.A., 1992. "Diagnostic value of antigen-binding lymphocytes assessment," J. Klinicheskaya laboratornaya diagnostika, 11-12, pp.4-10
 
Deryabin, P.N., Karalnik, B.V., Sultanbaev, T.Zh., 1993. Immunodiagnostics of inflamatory and septic infections. Almaty, Kazakhstan
 
Deryabin, P.N., Ponomaryova, T.S., Tugambaev, T.I., Atshabar, B.B., Arakelyan, I.S., 2012. "The use of immunomodulators to enhance the effectiveness of vaccination against plague," Proceedings of the 2nd International Conference on Vaccines and Vaccination, Chicago, USA
 
Feodorova, V.A. and Motin, V.L., 2012. "Plague vaccines: Current developments and future perspectives," Emerg Microbes Infect., November; 1(11): e36
 
Inglesby, T.V., Dennis, D.T., Henderson, D.A., Bartlett, J.G., Ascher, M.S. et al., 2000. "Plague as a biological weapon: Medical and public health management," Working Group on Civilian Biodefense, JAMA 284, pp.2281-2290
 
Karalnik, B.V., Denisova, T.G., 2011. "Immunomodulation, as a way of of studying immunoregulatory functions antigen binding lymphocytes," J Allergology and Immunology, Vol.12 (1), pp.54-55
 
Karalnik, B.V., Denisova, T.G., 2011. "Immunomodulation and stages of antigen specific response on herpes antigens," Medimond International Proceedings. IV World asthma and COPD forum and XVI international congress on rehabilitation in medicine and immunorehabilitation, pp.231-235
 
Karalnik, B.V., Deryabina, P.N., Denisova, T.G., Zhunusova, T.B., Berezin, B.E., 2001. "Antigen binding lymphocytes in dynamics of immune response to bacterial, viral and autoantigens," Izvestiya of the Ministry of Science, 5, pp.37-43
 
Karalnik, B.V., Leshchinskaya, T.S., 1981. "A process for preparing immunoreagent," USSR Certificate of Authorship No.862919, Bulletin of inventions, 34:30
 
March, C.J., Mosley, B., Larsen, A., Cerretti, D.P., Braedt, G., Price, V., Gillis, S., Henney, C.S., Kronheim, S.R., Grabstein, K., 1985. "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs", Nature, 315 (6021), pp.641-7, http://dx.doi.org/10.1038/315641a0
 
Medunicyn, N.V., 2010. Коррекция развития иммунитета при вакцинации, Биопрепараты, No.3(39), p.9, retreated from www.biopreparaty-magazine.ru
 
Omarova, M., Karalnik, B.V., Denisova, T.G., Kalymbetov, A., 2011. "Influence of immunomodulation on the first stage of antigen specific response to herpes vaccine in experiment," Medicala and health Science Journal, MHSJ, Vol.8, pp.21-26
 
Petrov, R.V., Khaitov, R.M., 2011. Immunogens and new generation vaccines, Moscow: GEOTAR Media
 
Ponomaryova, T.S., Deryabin, P.N., Tugambaev, T.I., Atshabar, B.B., 2010. "Polyoxidomum application for increase of live plague vaccine efficiency," Proceedings of the 10th Symposium International on Yersinia in Recife, Pernambuco, Brazil
 
Rall, U.M., 1965. Natural focality and epidemiology of plague, Moscow, 1965
 
Shamardin, V.A., Karalnik, B.V., 1981. Sensitization of erythrocytes using immunoglobulin. Methodic recommendations, Alma-Ata, Kazakhstan
 
Keywords Human recombinant interleukin-1beta, betaleukin, live plague vaccine, F1antigen, lymphocytes with F1-receptors, antibodies
DOI http://dx.doi.org/10.15208/mhsj.2014.04
Pages 27-34
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