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Volume 15
Issue 2
Online publication date 2014-07-20
Title Condition of the process of apoptosis in the human population with asymptomatic hyperuricemia
Author E.N. Tashkenbaeva, A.L. Alavi, D.Kh. Togaev, F.Sh. Kadirova
Abstract
59 patients at the age 46.4±3.49 years old have been observed, the first group consist of the patients with the normal level of uric acid in the blood (254.2 ± 16.01 mmol/l), the second group consist of the patients with the moderate level of uric acid in the blood (295.1 ± 15.83 mmol/l) and the third group consist of the patients with extremely high level of uric acid in the blood (until 350.0 ± 17.85 mmol/l). The performed investigations showed that the action balance of proapoptic and apoptic signals in the blood serum in asymptomatic hyperuricemy have been displaced from the initiation of metabolic processes to the accelerated apoptosis. This, possibly, is determined the development of cardio-vascular diseases, preparedness of cardiac hystiocytes, system of central hemodynamic and heart in the development of cardio-vascular disorders in patients with asymptomatic hyperuricemy. The determined appropriateness of connection of the increasing level of uric acid in the blood serum with the soluble types of apoptosis sFasL and sFas with the degree disorders of the NOS balance, increasing level of TNFα in patients with asymptomatic hyperuricemia could allow us to assume its importance in the development mechanisms of cardio-vascular pathology. They have principal importance for the prognosis and elaboration of the preventive methods of prevention and therapeutic approaches of correction of the determined abnormalities in the purine metabolism from the generally accepted normal levels of uric acid.

Citation
References
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Keywords Asymptomatic hyperuricemia, apoptosis, nitric oxide
DOI http://dx.doi.org/10.15208/mhsj.2014.06
Pages 39-43
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