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Volume 15
Issue 3
Title The brain damage in fetal alcohol syndrome (experimental and pathological study)
Author Zhanna Malakhova, Alexey Efremov
Abstract
The research compares clinical and experimental studies of the effects of antenatal alcohol exposure on the central nervous system development. The experimental model, involving Vistar rats, was used to analyze the effects of one-month alcohol intake before and during pregnancy. To conduct light-optical analysis we used brain of one-month-old rat offsprings.

Pathological studies of brain in infants with fetal alcohol syndrome (three lethal cases) revealed focuses of tissue rarefaction and dystrophic degeneration in the neurons along with a decreased amount of basket cells in the cerebellum. Such findings are in agreement with morphological analyses of brain, conducted on experimental animals.  
Moreover, employing heterogeneous solid-phase immunoassays, in experimental animals during pregnancy we analyzed the level of the transforming growth factor ß1 (ТGF- ß1).

Citation
References

Astley, S.J., Clarren, S.K., 1995. "A fetal alcohol syndrome screening tool", AlcoholClinExpRes., Vol.19(6), pp.1565-1571, http://dx.doi.org/10.1111/j.1530-0277.1995.tb01025.x
 
CDC, 2002. "Alcohol use among women of childbearing age, United States, 1991-1999," Morbidity and Mortality Weekly Report (MMWR), 51, pp.273-6
 
Miller, M.W., Robertson, S., 1993. "Prenatal expo-sure to ethanol alters the postnatal development and transformation of radial glia to astrocytes in the cortex," Journal of Comparative Neurologym, Vol.337, pp.253-266, http://dx.doi.org/10.1002/cne.903370206
 
Mirkes, P.E. (Ed.), 2003. "Congenital malformations surveillance report: A report from the national birth defects prevention network", Birth Defects Research, 67(9), pp.595-668
 
Ogura, Y., Takakura, N., Yoshida, H., Nishiikawa, S., 1998. "Essential role of platelet – derived growth factor receptor Alpha in the development of the intraplacental yolk sac sinus of Duval in mouse placenta," BiolReprod, Vol.58(1), pp.65-72, http://dx.doi.org/10.1095/biolreprod58.1.65
 
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Keywords Alcohol, fetal alcohol syndrome, growth factor
DOI http://dx.doi.org/10.15208/mhsj.2014.10
Pages 65-68
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