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Volume 16
Issue 2
Online publication date 2015-07-27
Title Role of a body’s proteinase-inhibitory system at grippe
Author Valentina Divocha
Abstract A new theory of grippe pathogenesis with participation of proteinase-inhibitory system has been offered. It has been established that purification and concentration of grippe viruses by different methods did not release the virus from cellular enzymes. At the experimental animals infecting with the virus of grippe, disturbance of enzyme-inhibitory balance took place, especially during first hours after the animals being infected. From the lungs of healthy mice, they have got six isoforms of trypsin-like proteinases. To all of them they got antiproteinase immune sera and have treated the experimental animals. It was antiserum to the third isoform that has prevented the experimental animals fatality.
Citation
References

Divocha V.O., 1998a. "Cellular components associated with virus of influenza", Odessa Med J., Vol.2(46), pp.8-10
 
Divocha V.O., 1998b. The method of inhibitor of trypsin-like proteases obtaining: Patent N 23548 A (Ukraine), IPC6 A61K25/00
 
Divocha V.O., 2000. Changes in chicken embryo at the action of influenza virus. Odessa Med J 2, pp.100-105
 
Divocha V.O., 2001. Inhibitor of trypsin-like proteases as antiviral remedy: Patent N 37324 A (Ukraine), IPC6 F61R31/14
 
Divocha V.A., Degtiarenko V.I., Zevakov V.F., 1983. "Cellular proteinase of influenza virus", The 2nd Congress of Infectionists of Ukraine: Abstracts. Kiev, pp.36-38
 
Divocha V.A., Mikhalchuk V.N., Gozhenko A.I., 2009a. "Molecular-and-biological substantiation of antiproteinase therapy of influenza", J Acad Med Scien Ukr Vol.15(1), pp.19-21
 
Divocha V.A., Mikhalchuk V.N., Gozhenko A.I., 2009b. "Trypsin-like proteinase and its inhibitors in vaccines and immunobiological preparations of blood", J Acad Med Scien., Vol.15(3), pp.609-25
Divocha V.A., Mikhalchuk V.N., Gozhenko A.I., 2011. Biological substantiation of antiproteinase therapy of influenza virus. Odessa: ART-V
 
Divocha V.A., Mikhalchuk V.N., Gozhenko A.I., 2012. "Dynamics of proteinase inhibitors, and the first phase of destruction of the body of white mice with experimental influenza virus", J Acad Med Scien Ukr, Vol.1(27), pp.133-136
 
Divocha V.O., Mikelashvili M.T., Mikhalcuk V.M., 2001. "The action of inhibitor of trypsin-like protease on influenza infection at the conditions of experiment", Infect Dis., Vol.2, pp.35-39
 
Divocha V.A., Sova Y.G., Mikelashvili M.T., 1995. Protective role of antiprotease immune sera at experimental influenza. I.I. Mechnikov's Ideas and the Development of Modern Natural Sciences: Abstracts of Scientific Conference, 28-30, November, Kharkov, pp.102-103
 
Divocha V.O., Sova Y.G., Mihkalchuk B.M., 2001. "Studying of physical-and-chemical properties of isoenzymes of trypsin-like proteinases", Med Chem., Vol.3(4), pp.31-34
 
Laemmli U.K., 1970. "Cleavage of structural proteins during the assembly of the head of bacteriophage", Nature, Vol.4(277), pp.680-685, http://dx.doi.org/10.1038/227680a0
 
Levitsky A.P., 1979. Methods for determination of trypsin inhibitors. Biochemical Methods of breeding material: Coll. Resear. Works Odessa, 15, pp.68-73
 
Lowry O.H., Rosenbrough N.Y., Farr A.L., Randai R.Y., 1951. "Protein measurement with the Folin phenol reagent", J of Biological Chemisrty 193, pp.265-275
 
Savinova O.V., Pavlova N.I., Boreko Y.I., 2008. "Individual and complex use of new derivatives of betulin and remantadin for inhibition influenza virus reproduction. Modern Problems of Humans Infectious Pathology", Collected Scientific Works. Minsk (Belorussia): Belprint, 1, pp.137-41
 
Shevchenko Y., Burtseva Y., Ivanova N., 2007. Specific ant influenza chemical preparations, substantiation of their use for prophylaxis and treatment in Russia: Urgent Problems of Infectious Pathology and Vaccine Prophylaxis in Children, 13-14 December, Moscow: Abstracts, pp.36-38
 
Veremeenko K.H., 1980. Enzymes in otolaryngologists. Kiev: Health
 
Vovchuk S.V., 1979. "Determination of activity of proteolytic enzymes in the grain cereals", Biochemical methods of breeding material, 15, pp.69-74
Keywords Proteinase-inhibitory system, grippe, trypsin-like proteinase
DOI http://dx.doi.org/10.15208/mhsj.2015.04
Pages 16-25
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