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Volume 18
Issue 1
Title Improving of treatment of non-exudative age-related macular degeneration
Author E.N. Bilalov, A.F. Yusupov, Sh.A. Mukhanov
Goal of research: Study of influence of the medotilin on clinical and functional conditions of eye in patients with non-exudative age-related macular degeneration (AMD).
Materials: Results of treatment of 68 patients (122 eyes) with non-exudative age-related macular degeneration (AMD). 2 groups were formed: Group 1 (control) - 34 patients (60 eyes) who received standard treatment; and the Group 2 (basic) - 34 patients (62 eyes) who received standard treatment in addition to medotilin.
Methods: Visometry, tonometry, computer perimetry, electroretinography (ERG) and color Doppler imaging (CDI). All studies were carried out before and after 1, 3 and 6 months after treatment.
Results: After treatment in the main group, in the first 3 months 95% of patients (59 eyes) showed a significant improvement of main functions of the eye. By the 6th month, 84% of patients (52 eyes) reported decline down to the original level, and 16% of cases (10 eyes) were stable and exceeded the data before the treatment. When registering macular ERG 1 month after treatment, the study group showed a significant improvement of figures, which remained consistently high also by the 3rd month of observation. By the 6th month of observation, figures declined slightly and came close to the original level. According to CDI, all patients of the main group recorded after treatment an increase in flows in vessels of the eye. Maximum peak increase of hemodynamic parameters were recorded by the 3rd month of observation. By the 6th month, the majority of patients in this group revealed regress of hemodynamic parameters, but at these, exceeded themselves in their capacity as such before treatment.
Conclusion: Medotilin is effective in treatment of non-exudative AMD and improves visual functions, confirmed by electroretinography and hemodynamics.
Bikbov ММ, Fayzrakhmanov RR, Yarmukhametova YL. Age-related macular degeneration [Vozrastnaya Makulyarnaya Degeneratsuya].  Мoscow: Ufa. 2013. 196p. Russian.

Gregori G, Wang F, Rosenfeld PJ, Yehoshua Z, Gregori NZ, Lujan BJ, Puliafito CA, Feuer WJ. Spectral domain optical coherence tomography imaging of drusen in nonexudative age-related macular degeneration. Ophthalmology. 2011;118(7):1373-1379.

Hartmann KI, Bartsch DU, Cheng L,  Kim JS, Gomez ML, Klein H, Freeman WR. Scanning laser ophthalmoscope imaging stabilized microperimetry in dry age-related macular degeneration. Retina. 2011;31(7):1323-1331.

Kiseleva ТN, Lagutina YM, Kravchuk EA. Role of vasoactive drugs in the therapy of non-exudative age-related macular degeneration. Refraction Surgery and Ophtalmology. Moscow. 2006;6(2):41-45. Russian.

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Leuschen JN, Schuman SG, Winter KP, McCall MN, Wong WT, Chew EY, Hwang T, Srivastava S, Sarin N, Clemons T, Harrington M, Toth CA. Spectral-domain optical coherence tomography characteristics of intermediate age-related macular degeneration. Ophthalmology. 2013; 120(1):140-150.

Monés J, Biarnés M, Trindade F, Arias L, Alonso, J. Optical coherence tomography assessment of apparent foveal swelling in patients with foveal sparing secondary to geographic atrophy. Ophthalmology. 2013;120(4):829-836.

Yehoshua Z, Wang F, Rosenfeld PJ, Penha FM, Feuer WJ, Gregori G. Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomography. Ophthalmology. 2011;118(2):2434-2441. 

Keywords Non-exudative age-related macular degeneration, medotilin, choline alfoscerate, electroretinography, color Doppler imaging, central artery of the retina, short posterior ciliary artery
Pages 14-20
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