Medical and Health Science Journal

  Previous Article | Back to Volume | Next Article
  Abstract | References | Citation | Download | Preview | Statistics
Volume 18
Issue 1
Title Clinical aspects of obstructive sleep apnea and comorbidities
Author Olga Chizhova
Abstract
Introduction: Obstructive sleep apnea (OSA) is associated with adverse health outcomes, particularly, with cardiovascular/metabolic disorders. 
Objectives: to evaluate signs of respiratory failure in patients with OSA without evidence of chronic airflow obstruction/restriction and to identify relations between abnormal respiratory pattern and associated cardiovascular and metabolic comorbidities in these patients. 
Methods: 360 males with mild, moderate and sever OSA underwent a clinical study with standard full night polysomnography. Breathlessness at baseline was assessed with Baseline Dyspnea Index, pulmonary function test and arterial blood gas analysis. Fasting and 2-hour glucose levels measured during an oral glucose tolerance test were used to assess glycemic status, as well as body mass index and waist-to-hip ratio. ECG and blood pressure monitoring were used to assess cardiovascular system.
Results: Presence of various cardiovascular and metabolic comorbidities in patients with OSA is correlated with intermittent hypoxemia and hypercapnia and can be predicted by the severity of OSA.
Conclusions: The results allow us to suggest that severe abnormal nocturnal pattern of breathing in OSA patients is resulted in respiratory failure even without presence of chronic airflow obstruc-tion/restriction.  Presence of various cardiovascular and metabolic comorbidities in patients with OSA is correlated with intermittent hypoxemia and hypercapnia and can be predicted by the severity of OSA.  
Citation
Keywords Obstructive sleep apnea, chronic respiratory failure, cardiovascular and metabolic disorders
Download Full PDF Download
  Previous Article | Back to Volume | Next Article
Share
Search in articles
Statistics
Journal Published articles
MHSJ 940
Journal Hits
MHSJ 2214845
Journal Downloads
MHSJ 16962
Total users online -