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Volume 3
Issue 3
Online publication date 2010-09-15
Title Clinical, diagnostic and molecular genetic features of chronic mixed-hepatitis B C in Uzbekistan
Author Botir Тadjiev
Abstract The study established the frequency of detection of antigens and antibodies to HBV and HCV in mixed-hepatitis B C. The highest rates of detection of serological markers were observed in the identification in the blood the HBV genotype D and HCV genotype 1b. This phenomenon can be explained by the high replicative and antigenic activity of viruses in these genotypes, resulting in a high viral load in blood, compared with HBV genotypes A and C,  HCV genotypes 3a and 2a. In this regard, the use of ELISA technique in combination with PCR diagnosis and genotyping of viruses is considered as desirable for the etiological interpretation of viral hepatitis. This approach also will enhance achieving the correct diagnosis and adequate choice of treatment programs.
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Keywords HBV, HCV, chronic mixed-hepatitis, genotype, pathological process.
Pages 47-51
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