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Volume 3
Issue 3
Online publication date 2010-09-15
Title Clinical, diagnostic and molecular genetic features of chronic mixed-hepatitis B C in Uzbekistan
Author Botir Тadjiev
Abstract The study established the frequency of detection of antigens and antibodies to HBV and HCV in mixed-hepatitis B C. The highest rates of detection of serological markers were observed in the identification in the blood the HBV genotype D and HCV genotype 1b. This phenomenon can be explained by the high replicative and antigenic activity of viruses in these genotypes, resulting in a high viral load in blood, compared with HBV genotypes A and C,  HCV genotypes 3a and 2a. In this regard, the use of ELISA technique in combination with PCR diagnosis and genotyping of viruses is considered as desirable for the etiological interpretation of viral hepatitis. This approach also will enhance achieving the correct diagnosis and adequate choice of treatment programs.
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References
Aryamkina, O., Klimov, N., Kovalenko, E. et al., 2001. “Clinical characteristics of patients with diffuse chronic liver diseases of viral HBV-and HCV-etiology,” Rus.  Journal of Gastroenterol. Gepatol. Koloproktol.,  No1(12), p.5

Gorbakov, V., Blokhina, N., Khazanov, A. et al., 2001. “The frequency of detection of HBV-DNA in serum HBsAg carriers and patients with simultaneous detection of anti-HCV and HBsAg,” Rus. Journal of Gastroenterol. Gepatol. Koloproktol.,  No1(12), p.9

Knodel, R., Ishak, K., Black, W., 1981. “Formulation and application of numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis,” Hepatology, 1(1), pp.431-35

Korochkina, O., Sobolevskaya, O., 1996. “Virus specific T-lymphocytic reaction in predicting the threat of chronic mixed hepatitis B C,” Rus. Journal of Gastroenterol. Gepatol. Koloproktol., No4(3), p.178

Liaw, Y., Tsai, S., Chang, J. et al., 1994. “Displacement of hepatitis B virus by hepatitis C virus as the cause of continuing hepatitis,” Gastroenterology, 106, pp.1048-1053
 
Mimms, L., Mosley, J., Hollinger, B. et al., 1993. “Effect of concurrent acute infection with hepatitis C virus on acute hepatitis B virus infections,” British Medical Journal, 307, pp.1095-1097

Sato, S., Fujiyama, S., Tanaka, M. et al., 1994. “Coinfection of hepatitis C virus in patients with chronic hepatitis B infection,” J. Hepatology, 21, pp.159-66

Serfaty, L., Chazouilleres, O., Poujol-Robert, A. et al., 1997. “Risk factors for cirrhosis in patients with chronic hepatitis C virus infection: Results of a case-control study,” Hepatology, 26(3), p.776

Sheen, I., Liaw, Y., Chu, C. et al., 1992. “Role of hepatitis C virus infection in spontaneous hepatitis B surface antigen clearance during chronic hepatitis B infection,” J. Infect Dis., 165, pp.831-34

Shkurko, T., 1998. “Clinical and diagnostic features of mixed HBV / HCV-infection in adults,” Synopsis of doctoral dissertation

Zaika, G., Gileva, R., Zakharova et. al., 2001. “Clinical and biochemical differences in hepatitis C and C B in acute and chronic stages,” Rus.  Journal of Gastroenterol. Gepatol. Koloproktol, No1(12), p.11 

Zhdanov, K., Lobzin, Y., Mukomolov, C., 1996. “ Clinical and morphological study of subclinical forms of infection with hepatitis B and C in young age,” Rus.  Journal of Gastroenterol. Gepatol. Koloproktol, No4 (3), p.174

Keywords HBV, HCV, chronic mixed-hepatitis, genotype, pathological process.
DOI http://dx.doi.org/10.15208/mhsj.2010.45
Pages 47-51
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