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Volume 3
Issue 3
Online publication date 2010-09-15
Title Features of balance of proinflammatory and anti-inflammatory cytokines in newborns with herpes virus infections
Author Zukhra Rakhmankulova
Abstract

The paper examines features of balance between proinflammatory and anti-inflammatory cytokines in newborns of mothers with herpes virus infections (SHV, CMVI). This investigation included 35 newborns, of them 10 were full-term newborns of healthy mothers (group 1 - umbilical blood); 10 - full-term newborns with  various pathology of perinatal period in mothers with intrauterine infections (group 2 - umbilical blood); 15 practically healthy newborns of healthy mothers (control group - peripheral blood). The paper studies production of proinflammatory IL-1b, IL-8, γ-IFN and anti-inflammatory (IL-4) cytokines in newborns in norm and with intrauterine infections.

The study has shown that the level IL-4 in the umbilical blood in newborns born from the mothers with intrauterine infection did not differ from a level in peripheral blood of healthy newborns. It has found also that there was 1.5 times increase of IL-1b in newborns with intrauterine infection in the umbilical blood in comparison with umbilical blood in healthy newborns, 3.4 times increase in IL-8 and the tendency to increase IFN-gamma.

Citation
References
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Ignatov, P., 2002. Immunity and Infection, Moscow, Vrema (the Time), pp.97-105

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Zdravkovic, M, Knudsen, H., Liu, X., Hager, H. et al., 1997. “High interferon alfa levels in placenta, maternal, and cord blood suggest a protective effect against intrauterine herpes simplex virus infection,” L Med Virol., Vol.51 (3), pp.210-213

Keywords Cytokines, interleukins, interferon.
DOI http://dx.doi.org/10.15208/mhsj.2010.46
Pages 52-55
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