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Volume 3
Issue 3
Online publication date 2010-09-15
Title Treatment of posttraumatic stress disorder - related nightmares and other sleep disturbances with risperidone in combat veterans and victims of domestic and childhood abuse
Author Nina Khachiyants
Abstract Sleep disturbances including nightmares are often reported as hallmark of posttraumatic stress disorder (PTSD). The literature related to the pharmacological treatment of PTSD-related nightmares is sparse and inconclusive. After reviewing the literature it was obvious that currently a limited data on studies supporting the use of antipsychotic medications for the treatment of PTSD are published. Moreover, even more limited scientific evidence is now available to formulate evidence-based guidelines for the treatment of  PTSD-related nightmares which are often reported as the most intrusive and disruptive symptom. Objective for this study is to review comprehensively the current research literature which reflects use of antipsychotic medication risperidone for the treatment of PTSD-related nightmares of different etiology.
Ahearn, E., Krohn, A., Connor, K., Davidson, J., 2003. “Pharmacologic treatment of posttraumatic stress disorder: A focuson antipsychotic use,” Annals of Clinical Psychiatry. Vol.15, No4/4, September/December, pp.193-201

American Psychiatric Association, 2000. Diagnostic and statistical manual of mental disorders, Fourth Edition, Text Revision( DSM-IV-TR),  Washington, DC

Bartzokis, G., Lu, P., Turnere, J., Mintz, J., Saunders, C., 2005. “Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder,” Biol Psychiatry, 57 (5), pp.474-79

Chambers, E., Belicki, K., 1998. “Using sleep dysfunction to explore the nature of resilience in adult survivors of childhood abuse or trauma,” Child Abuse Negl., 22, pp.753-58

David, D., DeFaria, L., LaReyra, O. et al., 2003. Adjunctive risperidone treatment in combat veterans with chronic PTSD, Poster presented at the 23rd Annual Conference of the Anxiety Disorders Association of America, March 29th, Toronto, Canada

David, D., De Faria, L., Mellman, T., 2006. “Adjunctive risperidone treatment and sleep symptoms in combat veterans with chronic PTSD,” Depression and anxiety, 23, pp.489-91

DeFazio, V., Rustin, S., Diamond, A., 1975. “Symptom development in Vietnam era veterans,” Am J Orthopsychiatry, 45, pp.158-63

Eidelman, I. Seedat, S, Stein, D., 2000. “Risperidone in the treatment of acute stress disorder in physically traumatized inpatients,” Depress Anxiety, 11, pp.187-88

Guerrero, J., Crocq, M., 1994. “Sleep disorders in the elderly: Depression and posttraumatic stress disorder,” J Psychosom Res, 38(Suppl.1), pp.141-50

Hammer, M., Faldowski, R., Ulmer, H., Frueh, B. et al., 2003. “Adjunctive risperidone treatment in post-traumatic stress disorder: apreliminary controlled trial of effects on comorbid psychotic symptoms,” Clin Psychopharmacol., 18 (1), pp.1-8

Inman, D., Silver, S., Doghramji, K., 1990. “Sleep disturbances in posttraumatic stress disorder: A comparison with non-PTSD insomnia,” Journal of Traumatic Stress, 3, pp.429-37

Kozaric-Kovacic, D., Pivac, N., Muck-Seler, D., Olasov Rothbaum, B., 2005. “Risperidone in psychotic combat-related posttraumatic stress disorder: An open trial,” . J Clin Psychiatry, 66, pp.922-27

Krashin, D., Oats, E., 1999. “Risperidone as an adjunct therapy for posttraumatic stres disorder,” Mil Med., 8, pp.605-606

Krystal, A., Davidson, J., 2007. “The use of prazosin for the treatment of trauma nightmares and sleep disturbances in combat veterans with PTSD,” Biol. Psychiatry, 61(8), pp.952-27

Leyba, C., 1998. “Risperidone in PTSD,” Psychistr Serv., 49, pp.245-46

Mellman, T., Kulick-Bell, R., Ashok, L., Nolan, B., 1995. “Sleep events among veterans with combat-related posttraumatic stress disorder,” American Journal of   Psychiatry, 152, pp.110-15

Monnelly, E., Ciraulo, D., 1999. “Risperidone effects on irritable aggression in posttraumatic stress disorder,” J Clin Psychopharmacol, 19, pp.377-78

Monnelly, E., Ciraulo, D., Knapp, C., Keane, T., 2003. “Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder,” J Clin Psychopharmacol., 23 (2), pp.193-96

Neylan, T., Marmar, C., Mertzler, T., Weiss, D. et al., 1998. “Sleep disturbance in the Vietnam generation: Findings from a nationally representative sample of male Vietnam veterans,” Am J Psychiatry, 155, pp.929-33

Padala, P., Madison, J., Monnahan, M., Marcil, W. et al., 2006. “Risperidone monotherapy for post-traumatic stress disorder related to sexual assault and domestic abuse in women,” Int Clin Psychopharmacol., 21 (5), pp.275-80

Rasmusson, A., Charney, D., 1997. “Animal models of relevance to PTSD,” Ann. NY Acad. Sci., 82, pp.332-51

Reich, D., Winternitz, S, Hennen, J., Watts, T., Stanculescu, C., 2004. “A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women, ” J Clin Psychiatry, 65 (12), pp.1601-606

Ross, R., Ball, W., Sullivan, K., Caroff, S., 1989. “Sleep disturbances as the hallmark of posttraumatic stress disorder,” Am J Psychiatry, 146, pp.697-707

Schotte, A., Janssen, P., Gommeren, W. et al., 1996. “Risperidone compared with new and reference antipsychotic drugs: In vitro and in vivo receptor binding,” Psychopharmacology (Berl), 124, pp.57-73

Shin, L., Wright, C., Cannistraro, P. et al., 2005. “A functional magnetic resonance imaging study of amygdale and medial prefrontal cortex responses to overtly presented fearful faces in PTSD,” Arch. Gen Psychiatry, 62(3), pp.273-278

Van der Kolk, B., Hartman, E., Burr, A,. Blitz, R., 1980. “A survey of nightmare frequency in a veteran’s outpatient clinic,” Sleep Res., 9, p.229

Woodward, S., Arsenault, N., Murray, C., Bliwise, D., 2000. “Laboratory sleep correlates of nightmare compliant in PTSD inpatients,” Biol Psychiatry, 48, pp.1081-1087

Keywords Posttraumatic stress disorder, nightmares, Risperidone.
Pages 60-66
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