Medical and Health Science Journal

  Previous Article | Back to Volume | Next Article
  Abstract | References | Citation | Download | Preview | Statistics
Volume 4
Issue 4
Online publication date 2010-12-10
Title Genetic aspects of endothelium dysfunction in Uzbek hypertensive patients
Author Gulnoza Khamidullaeva, Amayak Kevorkov, Marietta Eliseyeva
Abstract The objective of the study was to evaluate the prevalence of ACE/ID, AGT/M235T, AT1R/A1166C, CYP11B2/C344T, B2ВKR/ 9-9, ecNOS/4a4b, GNB3/C825T, and ARB2/Gln27Glu gene polymorphisms and their association with endothelium dysfunction (ED) in Uzbek hypertensive patients. The study found an association between ED and AGT M235T gene polymorphism. Genetic models disclosed that the T-allele, MT-, and TT-genotypes of the AGT gene were associated with an increased risk of ED. However, multivariate logistic regression analysis confirmed the negative association between the MM genotype of the AGT gene and positive association between IMT and ED. An association between essential hypertension (EH) in Uzbek males with ACE/ID and GNB3/C825T gene polymorphisms has been demonstrated. There is an association of AGT/ M235T gene polymorphism and ED in Uzbek hypertensive patients.
Alvarez, R., Reguero, J., Batalla, A., Iglesias-Cubero, G. et. al., 1998. “Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms: association with early coronary disease,” Cardiovascular Research, Vol.40, pp.375-79

Beige, J., Hohenbleicher, H., Distler, A., Sharma, A., 1999. “G-protein β3 subunit C825T variant and ambulatory blood pressure in essential hypertension,” Hypertension, Vol.33, pp.1049-1051

Berge, K., Berg, K., 1994. “No effect of insertion/deletion polymorphism at the angiotensin I-converting enzyme locus on normal blood pressure levels or variability,” Clin. Genet., Vol.45, pp.169-74

Bengtsson, K., Orho-Melander, M., Melander, J., Lindblad, U. et. al., 2001. “β2-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes,” Hypertension, Vol.37, pp.1303-308

Benjafield, A., Jeyasingam, C., Nyholt, D., Griffiths, L. et. al., 1998. “G-protein β3 subunit gene (GNB3) variant in causation of essential hypertension,” Hypertension, Vol.32, pp.1094-097

Bohn, M., Berge, K., Bakken, A., Erikssen, J. et. al., 1993. “Insertion/deletion polymorphism at the locus for angiotensin I-converting enzyme and myocardial infarction,”  Clin. Genet., Vol.44, pp.292-97

Bonnardeaux, A., Davies, E., Jeunemaitre, X., Fery, I. et. al., 1994. “Angiotensin II type I receptor gene polymorphism in human essential hypertension,” Hypertension. Vol.24, pp.63-69

Brand, E., Hermann, S., Nicaud, V., Ruidavets, J. et. al., 1999. “The 825C/T polymorphism of the G-protein subunit β3 is not related to hypertension,”  Hypertension, Vol.33, pp.1175-178

Cambien, F., Poirier, O., Lecerf L., Evans A. et. al., 1992. “Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction,” Nature, 359. pp.641-44

Celermajer, D., Sorensen, K., Gooch, V., Spiegelhalter, D. et al., 1992. “Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis,” Lancet. 340. pp.1111-115

Corretti, M., Anderson, T., Benjamin, E., Celermajer, D. et al., 2002. “Guidelines for the ultrasound assessment of endothelial dependent flow-mediated vasodilation of the brachial artery. A report of the international brachial artery reactivity task force, ” J Am Coll Cardiol., 39, pp.257-265

Demirel, S., Akkaya, V., Cine, N., Oflaz, H. et. al., 2005. “Genetic polymorphisms and endothelial dysfunction in patients with essential hypertension: a cross-sectional case-control study,” Neth. Heart. J., Vol.13, pp.126-31
Dhamrait, S., Paine, J., Li, P., Jones, A. et. al., 2003. “Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension,” Eur. Heart. J., Vol.24, pp.1672-680

Dong, Y., Zhu, H., Sagnella, G., Garter, N. et. al., 1999. “Association between the C825T polymorphism of the G protein β3-subunit gene and hypertension in blacks,” Hypertension, Vol.34, pp.1193-196

Izawa, H., Yamada, Y., Okada, T., Tanaka, M. et. al., 2003. “Prediction of genetic risk for hypertension,” Hypertension, Vol.41, pp.1035-1040

Jeunmaitre, X., Lifton, R., Hunt, S., Williams. R. et. al., 1992. “Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension,” Nature Genet., Vol.1, pp.72-75

Jeunemaitre, X., Soubrier, F., Kotelevtsev, Y., Lifton, R. et. al., 1992. “Molecular basis of human hypertension: Role of angiotensinogen,” Cell, Vol.71, pp.169-80

Kearney, P., Whelton, M., Reynolds, K., Muntner, P. et al., 2005. “Global burden of hypertension: Analysis of worldwide data,” Lancet, Vol.365. pp.217-23

Kupari, M., Hautanen, A., Lankinen, L., Koskinen, P. et. al., 1998. ”Association between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function,” Circulation. Vol.97, pp.569-75

Linder, L., Kiowsky, W., Bühler, F., Lüscher, T., 1990. “Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension,” Circulation. Vol.81, pp.1762-767

O’Donell, C., Lindpainter, K., Larson, M., Rao, V. et. al., 1998. “Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with essential hypertension and blood pressure in men but not women in the Framingham Heart Study,” Circulation, Vol.97, pp.1766-772

Panza, J., 1997. “Endothelial dysfunction in essential hypertension,” Clin Cardiol, Vol.11. pp.26-33

Panza, J., Quyyumi, A., Brush, J., Epstein, S., 1990. “Abnormal endothelium dependent vascular relaxation in patients with essential hypertension,” N. Engl J Med., 323, pp.22-27

Perticone, F., Ceravolo, R., Maio, R., Venmtura, G. et. al., 1998. “Angiotensin-converting enzyme polymorphism is associated with endothelium-dependent vasodilation in never treated hypertensive patients,” Hypertension, Vol.31, pp.900-905
Rossi, G., Taddei, S., Virdis, A., Ghiadoni, L. et. al., 2001. “Exclusion of ACE D/I gene polymorphism as a determinant of endothelial dysfunction,” Hypertension, Vol.37, pp.293-300

Rossi, G., Taddei, S., Virdis, A., Cavallin, M. et. al., 2003. “The T-786C and Glu298Asp polymorphism of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients,” J. Am. Coll. Cardiol., Vol.41, pp.946-48

Russ, A., Maerz, W., Rũzicka, V., Stein, U. et. al., 1993. “Rapid detection of the hypertension associated Met235Thr allele of the human angiotensinogen gene,” Hum. Mol. Genet. Vol.2, pp.609-10

Samani, N., Thompson, J., O’Toole, L., Channer, K. et. al., 1996. “A metaanalysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction,” Circulation, Vol.94, pp.708-12

Schunkert H., Hense H., Holmer S., Stender M. et. al., 1994. “Association between a deletion polymorphism of the angiotensin converting gene and left ventricular hypertrophy,” New. Eng. J. Med., Vol.30, pp.1634-638

Shioji, K., Kokubo, Y., Mannami, T., Inamoto, N. et. al., 2004. “Association between hypertension and the α-adducin, β1-adrenoreceptor, and G-protein β3 subunit genes in the Japanese population; the Suita study,” Hypertens. Res.,Vol.27, pp.31-37

Siffert, W., Rosskopf, D., Siffert, G., Busch, S. et. al., 1998. “Association of a human G-protein beta3 subunit variant with hypertension,” Nat. Genet., Vol.18, pp.45-48

Stein, J., Korcarz, C., Hurst, R., Lonn, E. et al., 2008. “Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American society of echocardiography carotid intima-media thickness task force endorsed by the society for vascular medicine,” J. Am. Soc. Echocardiogr., Vol.21, pp.93-111

Tiret, L., Bonnardeux, A., Poirier, O., Ricard, S. et. al., 1994. “Synergistic effects of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on risk of myocardial infarction,” The Lancet, Vol.344, pp.910-13

Turner, S., Boerwinkle, E., Sing, C., 1999. “Context-dependent associations of the ACE I/D polymorphism with blood pressure,” Hypertension, Vol.34, pp.773-78
Zateyshchikov, D., Minushkina, L., Kudryashova, O., Chistyakov, D., 2000. “NO-synthase gene and endothelium-related hemostasis in patients with coronary heart disease,” Kardiologiya, Vol.11, pp.28-32

Zee, R., Lou, Y., Griffiths, L., Morris, B., 1992. “Association of a polymorphism of the angiotensin I-converting enzyme with essential hypertension,” Biochem. Biophys. Res. Commun., Vol.184, pp.9-15

Keywords Essential hypertension, endothelial dysfunction, gene polymorphisms
Pages 30-36
Download Full PDF Download
  Previous Article | Back to Volume | Next Article
Search in articles
Journal Published articles
MHSJ 940
Journal Hits
MHSJ 2213208
Journal Downloads
MHSJ 16957
Total users online -