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Volume 5
Issue 1
Online publication date 2011-03-01
Title Pathogenic value of electric disruption changes and erythrocytes membrane microviscosity in calculous pyelonephritis in children and ways of their correction
Author Nurlepes Utegenov, Mahmud Aliev, Abdusattar Nasirov, Bilim Terebaev
Abstract Electrical disruption in erythrocyte membranes  and their microviscosity were  defined in  194 patients with acute suppurative form of calculous pyelonephritis (CP) in 3 weeks and in 3 months after basic or metabolic therapy. 24 practically healthy children aged from 5 to 14 years were examined as well. Electrical disruption in erythrocyte membranes in practically healthy children occurred with index 135.4 mV. In patients with acute suppurative form of CP this index was 62.4 мV, in group of patients with acute serous form of CP - 73 мV , in children with latent form of CP - 78 мV.  Considerable decrease of electrical membrane stability resulted in 43-46% of patients with acute suppurative form of CP in bilateral numerous stones, as compared with control group. Corrected role of complex using of vitamin coenzymes, antioxidants and antiaggregants stabilizes metabolic tubular acidosis of kidneys, blockades inflammatory process activity, inhibits formation of saline sediments (phosphates,oxalates, uric acid,calcium) and  normalizes ion permeability of  cellular membranes.
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Keywords Calculous pyelonephritis, metabolic treatment, erythrocytes electrical membrane disruption, microviscosity
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