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Volume 5
Issue 1
Online publication date 2011-03-01
Title Comparative bioequivalence study of meloxicam drugs
Author Ekut Karieva, Khаlida Yunusova
Abstract The governments of many countries strongly support the production and clinical use of generic medicinal products which are “copies” of patented drugs and can be marked at lower cost. At present time bioequivalence testing is regarded as a useful methodology to perform comparisons among different products containing the same active ingredient. This report presents the results of comparative bioequivalence study of three meloxicam formulations: brand-drug “Melbek” with tablets and capsules of meloxicam developed at the Tashkent Pharmaceutical Institute. The results obtained confirm the bioequivalence of the studied drugs, which indicate about scientifically based approach to the selection of excipients and technological process in the development of the above generic drugs.
Belousov, Y., 2003. “Generics - Myths and Realities,” Remedium [Remedium], in Russian, No.7-8, pp.4-9

DH RF, 2005. Guide to Clinical Trials. Drugs. Bioavailability and bioequivalence studies

EMEA, 2001. Note for guidance on the investigation of bioavailability and bioequivalence, London

FDA, 2003. Guidance for industry: Bioavailability and bioequivalence studies for orally administered drug products, Department of Health and Human Services, Rock-Ville

Meshkovskii, A., 2003.  “Place of generics in the pharmaceutical supply,” Farmateka [Farmateka], in Russian, No.3, pp.103-104
NIHS, 2000. Guideline for bioequivalence studies for different strengths of oral solid dosage forms, Japan

Panyushin, R., 2003. “The original and generic drugs: The unity or the struggle of opposites?”, Pharm. Gazette [Farmacevticheskiy Vestnik], in Russian, No.16, pp.23-25
Shoenfeld, P., 1999. “Gastrointestinal safety profile of meloxicam: A meta-analysis and systematic review of randomized controlled trials,”Am J Med., Vol.107 (6A), pp.48-54

Shostak, N., Shemetov, D., 2001. “Efficacy and tolerability of meloxicam (Movalis) syndrome of pain in his lower back when compared with diclofenac,” Scientific and Practical. Revmatol
 [Nauchno-prakticheskiy Revmatolog], in Russian, No.1, pp.63-67
Tsvetkova, E., 2001. “Movalis in osteoarthrosis therapy,” Scientific and Practical. Revmatol. [Nauchno-prakticheskiy Revmatolog], in Russian, No.1, pp.67-71

Keywords Non-steroid anti-inflammatory drugs, meloxicam, Dissolution test, bioequivalence
Pages 112-114
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