Medical and Health Science Journal
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| Volume | 6 |
| Issue | 2 |
| Online publication date | 2011-04-04 |
| Title | The analysis of the genetic structure of the Kazakh population as estimated from mitochondrial DNA polymorphism |
| Author | Galina Berezina, Gulnara Svyatova, Zhanar Makhmutova |
| Abstract | The study polymorphism of mitochondrial DNA carried out in population of Kazakhs (N=304). The analysis shows that Western Europe (55%) and Eastern Europe (41%) mtDNA lineages exist in the Kazakhs population. A high genetic diversity was observed in the Kazakhs population (h=0.996). Nei’s genetic distances using mtDNA haplogroups frequencies are calculated and the situation of the Kazakhs among other peoples is determined. The paper offers analysis of the genetic structure of the Kazakh population using data of the frequencies of mtDNA haplogroups. It is noted a high degree of intensity of gene exchange between the Kazakh population and frontier populations of Russia on the North-West, North, Northeast and East of Kazakhstan |
| Citation | |
| References | Anderson, S., Bankier, A., Barrell, B. et. al., 1981. “Sequence and organization of the human mitochondrial genome,” Nature, Vol.290, pp.457-65 Batyrova, A., 2004. “The analysis of DNA polymorphism of nuclear and mitochondrial genomes in populations of Central Asia” [Analiz polimorfizma DNK yadernogo i mitohondrialnogo genomov v populjaciyah Sredney Azii], in Russian, Ufa Comas, D., Calafell, F., Mateu, E. et. al., 1998. “Trading genes along the silk road: mtDNA sequences and the origing of Central Asian populations,” Am. J. Hum. Genet., Vol.63, pp.1824-838 Ismagulov, O., 1970. “The population of Kazakhstan from Bronze Age until now” [Naselenie Kazakhstana ot epohi bronzi do sovremennosti], in Russian, Science Publishing House of the Kazakh SSR, Alma-Ata Khusnutdinova, E., 1999. “Molecular etnogenetiks of peoples in the Volga-Ural region” [Molekuljarnaya эtnogenetika narodov Volgo–Uralskogo regiona], in Russian, Ufa: Guillem Kolman, C., Sambuughin, N., Bermingham, E., 1996. “Mitochondrial DNA analysis of Mongolian populations for the origin of New World founders,” Genetics, Vol.142, pp.1321-334 Limborskaya, S., Khusnutdinova, E., Balanovskaya, E., 2002. “The ethnogenomics and genogeography peoples of Eastern Europe” [Etnogenomika i genogeografiya narodov Vostochnoy Evropi], in Russian, Moscow Macaulay, V., Richards, M., Forster, P. et al., 1999. “The emerging tree of West Eurasian mtDNAs: A synthesis of control-region sequences and RFLPs,” Am. J. Hum. Genet.,Vol.64, pp.232-49 Miller, S., Dyckes, D., Polesky, H., 1988. “A simple salting out procedure for extracting DNA from human nucleated cells,” Nucl.Acids.Res., Vol.16, pp.1215 Nei, M., 1988. “Molecular evolutionary genetics,” New York: Columbia University Press Rychkov, Yu., Balanovskaya, E., 1992. “The gene pool and genogeography Soviet population,” Genetics [Genetika], in Russian, Vol.2, No.16, pp.52-75 Torroni, A., Schurr, T., Cabell, M. et al., 1993. “Asian affinities and continental radiation of the four founding native American mtDNAs,” Am. J. Hum. Genet., Vol.53, pp.563-90 Wallace, D., Lott, M., Brown, M., et al., 1995. “Report of the Committee on human mitochondrial DNA”, in.: Citicchia, A. (Ed.), Human gene mapping: A compendium, Johns Hopkins University: Johns Hopkins University Press, pp.910-54 Ward, R., Frazier, B., Dew, K., Paabo, S., 1991. “Extensive mitochondrial diversity within a single Amerindian tribe,” Proc. Natl. Acad. Sci. USA, Vol.88, pp.8720-724 |
| Keywords | Mitochondrial DNA, polymorphism, genetic structure |
| DOI | http://dx.doi.org/10.15208/mhsj.2011.99 |
| Pages | 2-6 |
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