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Volume 6
Issue 2
Online publication date 2011-04-04
Title The role of polymorphisms in genes of folate metabolism and hyperhomocysteinemia in realization of missed abortion in the Ist trimester
Author Nagima Mamedaliyeva, Alija Aimbetova, Gulnara Svyatova

The article explores mechanisms of non-developing the Ist trimester pregnancy on the basis of studying frequency of polymorphic alleles in folate metabolism genes MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G, homocysteine level, platelet and plasma haemostasis sections.

Polymorphism in MTHFR, MTRR, and MTR genes of folate metabolism causes hyperhomocysteinemia and thrombophilic changes. In conditions of genetically accustomed thrombophilic changes the desynchronization of fibrinolysis and fibrin formation processes during implantation occurs that leads to poor trophoblast invasion and its inadequacy, which in turn causes miscarriage due to non-developing pregnancy in the Ist trimester.
Fetisova, I., Dobrolyubov, A., Lipin, M., Polyakov, A., 2007. “Polymorphism of genes of folate metabolism and diseases in humans,” Bulletin of new medical technologies [Vestnik novih meditsinskikh tekhnologiy], in Russian, Vol.X, No.1

Fillipova, N., Guseva, O., 2008. “Efficacy of folic acid application in complex therapy of haemostatic disorders in pregnant women after IVF,” Problems of reproduction Journal [Jurnal Problemi reprodukcii], in Russian, No.2, pp.27-32

Ilizarova, N., Kuleshov, V., Chernyakina, O., 2008. “Use of folacin in patients with habitual miscarriage and extragenital abnormality in the presence of hyperhomocysteinemia,” Russian bulletin of obstetrician-gynecologist [Rossiiskiy vestnik akushera-ginekologa], in Russian, No.5, pp.61-65

Kulakovskiy, V., Sirtlanov, I., Frolov, A., 2007. “Characteristics of gestation course in women with non-developing pregnancy and fetal death history at different stages of gestation,” Journal of obstetrics and woman disease [Jurnal akusherstva i jenskikh bolezney], in Russian, Vol.LVI., 3rd edition, pp.107-112

Makatsaria, A., Bitsadze, V., Akinshina, S., 2007. Thrombosis and thromboembolism in obstetrics and gynecologic practice [Trombozi i tromboembolii v akushersko-ginekologicheskoy praktike], in Russian, Medical Information Agency LLC, Moscow

Ozolinya, L., Efimov, V., Abdulrab A., et al., 2003. “Hyperhomocysteinemia and obstetrical pathology,” Russian bulletin of obstetrician-gynecologist [Rossiiskiy vestnik akushera-ginekologa], in Russian, No.4, pp.26-29

Radzinskiy, V., Demidova, E., 2007. “The diagnostic and prognostic significance of genetic polymorphisms of C677T methylenetetrahydrofolate reductase, РIА/РIA2 glycoprotein IIIa, 4G/5G inhibitor of the I type plasminogen activator and R353Q VII factor in women with miscarriage,” Bulletin of the Peoples’ Friendship University of Russia [Vestnik RUDN; Obstetrics i Ginecologii], in Russian, No.5, pp.171-82

Rodgers, G., Kane, W., 1998. “Activation of endogenous factor V by a homocystein-induced vascular endothelial activator,” Journal Clin. Invest., Vol.77, pp.1909-916

Keywords Missing abortion, folate cycle, MTHFR, MTRR, MTR, hyperhomocysteinemia, thrombophilia
Pages 17-22
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