Medical and Health Science Journal

  Previous Article | Back to Volume | Next Article
  Abstract | References | Citation | Download | Preview | Statistics
Volume 8
Issue 4
Online publication date 2011-07-29
Title Intrauterine hypoxia of fetus - influence of ultra-low doses of antioxidant (experimental research)
Author Zarina Khaybullina
Abstract
Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen condition, but intensive production of reactive oxygen species (ROS) can cause cell destruction. Previous studies revealed that the hypoxia induces oxidative stress and neurodegeneration, which is associated with memory, behavioral, and learning-education impairment in children. In the view of the above-stated concept, the study of influence of ultra low doses of antioxidant on ROS generation and activity of enzymes of antioxidant protection in a brain and blood at intrauterine hypoxia of a fetus appears appealing. 
The effect of Fenozan in ultra low doses was evaluated in the rats underwent intrauterine hypoxia. Research was made on white rats, 66 pregnant females and 279 infant rats (0-21 days). It was established, that chronic pre-natal hypoxia is accompanied by accumulation of malondialdehyde in brain tissue, blood and subcellular fractions of a liver, with the subsequent spontaneous normalization of its maintenance by 21st day in a brain and blood. Fenozan injection in ultra low doses leads to appreciable decrease in MDA level and increase of the ROS-scavenging enzymes at first in a brain and peripheral blood, and then in microsomal and mitochondrial fractions of the liver, that is the precondition for normalization of pathological process in earlier terms. Significance of this data argues that ultra low doses of Fenozan can be less invasive and effective in the treatment of chronic intrauterine hypoxia and suggest the directions for further research.

Citation
References
Alekseeva, O., Kim, J., Mil, E., Albantova, A., Binjukov, V., Goloshchapov, A., Burlakova, E., 2010. “The comparative research of influence of hybrid antioxidants on structure and functions of components of biological membranes” [Sravnitelniy analyz vlyania hybridnich antioksidantov na strukturu I funksii biologicheskish membran], in Russian, The book of reports of the VIII International Conference “Bioantioxidant”, pp.16-17

Andrievsky, G., 2008. “Universal biological activity of hydrated fullerene and nanostructure as a key to understanding of laws of minor doses effect” [Universalnaya biologicheskaya aktivnost gidratirovannogo fullerene i ego nanostructury kak kluch k ponimaniyu zakonomernostey deistvia sverchmalysh doz], in Russian. The book of reports of the IV International Symposium “Mechanisms of effect of minor doses”, pp.6-7

Burlakova, E., 2010. “The bioantioxidants. A nanoworld of weak effects of “dwarfs”, its laws, a generality and distinctions with the world of “giants”” [Bioantioksidanty. Nanomir slabish vozdeystviy “karlikov”, ego zakony, obchnost i razlichya s mirom “gigantov”], in Russian. The book of reports of the VIII International conference “Bioantioxidant”, pp.69-71

Gabriel, G., Haddad, S., Ping Yu, 2009. Brain Hypoxia and Ischemia with Special Emphasis on Development, New-York: Humana Press

Gueraud, F., Atalay, M., Bresgen, N., Cipak, A., Eckl, P., Huc, L., I., Siems, W., Ucida, K., 2010. “Chemistry and biochemistry of lipid peroxidation products,” Free Radical Research, Vol.44, pp.1098-124

Mirsa, P., Fridovich, J., 1972. “The role of superoxide anion in the antioxidation of epinephrine and a simple assay for superoxide dismutase,” J. Biol. Chem., Vol.247, pp.3170-175

Panchman, M., Muthuraju, S., Ilavazhagan, G., Shashi, B., 2008. “Hypobaric hypoxia induces dendritic plasticity in cortical and hippocampal pyramidal neurons in rat brain,” Behavioral brain research, Vol.189, pp.233-43

Stalnaya, I., Gariašvili, T., 1977. Method for determination of malondialdehyde with thiobarbituric acid [Metod opredelenija malo novogo dial’degida s pomoshyu tiobarbiturovoj kisloti], in Russian, Moscow

Zubkova, B., 1976. “The quantities measurement of catalase activity in the blood”, [Metod kolichestvennogo opredeliniya katalazy v krovi], in Russian, Moscow: Medicine, pp.81-83

Keywords Hypoxia, reactive oxygen species, antioxidant, Phenazan
Pages 41-49
Download Full PDF Download
  Previous Article | Back to Volume | Next Article
Share
Search in articles
Statistics
Journal Published articles
MHSJ 940
Journal Hits
MHSJ 2252936
Journal Downloads
MHSJ 17025
Total users online -