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Volume 8
Issue 4
Online publication date 2011-07-29
Title Intrauterine hypoxia of fetus - influence of ultra-low doses of antioxidant (experimental research)
Author Zarina Khaybullina
Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen condition, but intensive production of reactive oxygen species (ROS) can cause cell destruction. Previous studies revealed that the hypoxia induces oxidative stress and neurodegeneration, which is associated with memory, behavioral, and learning-education impairment in children. In the view of the above-stated concept, the study of influence of ultra low doses of antioxidant on ROS generation and activity of enzymes of antioxidant protection in a brain and blood at intrauterine hypoxia of a fetus appears appealing. 
The effect of Fenozan in ultra low doses was evaluated in the rats underwent intrauterine hypoxia. Research was made on white rats, 66 pregnant females and 279 infant rats (0-21 days). It was established, that chronic pre-natal hypoxia is accompanied by accumulation of malondialdehyde in brain tissue, blood and subcellular fractions of a liver, with the subsequent spontaneous normalization of its maintenance by 21st day in a brain and blood. Fenozan injection in ultra low doses leads to appreciable decrease in MDA level and increase of the ROS-scavenging enzymes at first in a brain and peripheral blood, and then in microsomal and mitochondrial fractions of the liver, that is the precondition for normalization of pathological process in earlier terms. Significance of this data argues that ultra low doses of Fenozan can be less invasive and effective in the treatment of chronic intrauterine hypoxia and suggest the directions for further research.

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Keywords Hypoxia, reactive oxygen species, antioxidant, Phenazan
Pages 41-49
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