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Volume 8
Issue 4
Online publication date 2011-07-29
Title Investigation of association between bronchial asthma and gene FcεRIβ 109 C/T polymorphism in Uzbek population
Author Nazira Khaitova, Shukhrat Ziyadullaev, Rustam Mukhamedov
The molecular bases of predictive medicine are being actively developed at present. Conceptual basis for predictive medicine is presented by notion of genetic polymorphism. Among the set of candidate genes, the FcεRIβ gene being an important component of the hereditary component of susceptibility to asthma and atopy occupies big interest.
We studied the distribution of allele and genotype frequencies of polymorphic gene variant of high affinity IgE receptor (FcεRIβ) in patients in with different phenotypic variants of bronchial asthma and healthy individuals of Uzbek nationality. Material for the study included DNA samples from patients with asthma and healthy adolescents of Uzbek nationality. Amplification of loci was performed by PCR, genotyping was performed by polymorphism of length of restrictive fragments. 
The results of investigations of the polymorphic gene variant of  high affinity IgE receptor have shown that markers of increased risk of allergic form of bronchial asthma in adolescents  of Uzbek ethnicity are genotype FcεRIβ-109T/T and allele FcεRIβ-109T, markers of low-risk are FcεRIβ-109C/C and allele FcεRIβ-109C.

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Keywords Asthma, gene, polymorphism
Pages 55-58
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