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Volume 9
Issue 5
Online publication date 2011-11-05
Title Neuroendocrine carcinoma of the nasopharynx - A case report
Author Sethu Subha
Abstract Small cell neuroendocrine carcinoma, also known as oat cell carcinoma is a frequently encountered bronchogenic neoplasm.  Neuroendocrine carcinomas of the head and neck are rare aggressive tumors and pose a diagnostic and management challenge. Differentiation from conventional nasopharyngeal carcinoma is difficult due to morphological characteristics and small biopsy specimen. Distinguishing is very important because of   difference in natural history ,prognosis and treatment among these neoplasms. In this article we present an unusual case of 51 year old man with small cell neuroendocrine carcinoma of nasopharynx, who was treated with radiotherapy and achieved complete tumor remission. Subsequently he developed local recurrence and liver metastasis and succumbed to the disease.
Capelli, M., Bertino, G., Morbini, P. et al., 2007. “Neuroendocrine carcinomas of the upper airways: A small case series with histopathological considerations,” Tumori, Vol.93, pp.499-503

Ferlito, A., Caruso, G., Nicola, P. et al., 1981. “Primary small cell  [oat cell ]  carcinoma of the larynx and hypopharynx. A clinico-Pathological study of 8 cases with a review of the literature,” ORL J Otorhinolaryngology  Relat Spec., Vol.43, pp.204-22

Ferlito, A. and Polidoro, F., 1980. “Simultaneous primary oat cell carcinoma (apudoma) and squamous cell carcinoma of the hypopharynx,” ORL J Otorhinolaryngology Relat Spec., Vol.42, pp.146-57

Ferlito, A., Rinaldo, A., 2003. “Small cell neuroendocrine carcinoma of the larynx: A preventable and frustrating disease with a highly aggressive lethal behavior,” ORL J Otorhinolaryngology Relat Spec., Vol.65, pp.131-34

Klussmann, JP, Eckel, HE, 1999. “Small cell neuroendocrine carcinoma of the larynx,” Ear, Nose  Throat J., Vol.78, pp.22-24

Monroe, AT, Morris, CG, Lee, E.  et al., 2005. “Small cell carcinoma of the head and neck: The University of Florida Experience,”J HK Coll  Radiol., Vol.8, pp.83-86

Keywords Small cell neuroendocrine carcinoma, radiotherapy, nasopharynx, soft palate
Pages 101-103
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