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Title Α 75 year-old male with a solitary pulmonary mass, pleuritic pain and persistent fever
Author Zafeiris Sardelis, Loukas Thanos, Ioannis Vamvakaris, Kostantinos Gakis, Kostantinos Belentzas, Silvia Dumitrou, Epaminondas Kosmas
Abstract The lung is an extremely rare primary site for the development of malignant melanoma, in contrast with other tissues where this tumour presents, such as skin, head and neck mucosa, eyes and the gastrointestinal tract. Primary malignant melanoma of the lungs (PMML) is a diagnostic challenge, as clinically and radiologically it cannot be distinguished from the usual primary bronchogenic lung cancer, and its histopathological and immunohistochemical characteristics are little different from those of a lung metastasis from another primary site of malignant melanoma, which is more common. Its diagnosis is based on a number of clinical, radiological and histopathological criteria. In addition, because of its rarity, the knowledge and experience about the prognosis and treatment modalities concerning PMML are inadequate, due to lack of large series. From the little that we know, it appears to be a tumour with poor prognosis, which should be treated by radical surgery, if this is possible, followed by adjuvant chemotherapy and radiotherapy, practically the same as those used for skin melanomas. Metastases to the spleen are an unusual manifestation of malignant melanoma, and may be the cause of continuous high fever.
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References
1. Dountsis A, Zisis C, Karagianni E, Dahabreh J. Primary Malignant Melanoma of the Lung: A case report. World Journal of Surgical Oncology 2003;1:26

2. Pan Xu-dong, Zhang Bin, Guo Ling-chuan, Gu Dong-mei et al. Primary Malignant Melanoma of the lung in the elderly: case report and literature review. Chinese Medical J ournal 2010;123:1815-1817

3. Wilson RW, Moran CA. Primary melanoma of the lung: a clinicopathologic and immunohistochemical study of eight cases. Am J Surg Pathol 1997;21:1196-202.

4. Winston W. Tan: Malignant melanoma. e-medicine oncology, www.e-medicine.medscape.com, Date updated: June 1, 2010.

5. Kim Kevin. Non – Skin Melanomas. Cancer blog from MD Anderson Cancer Center, www.mdanderson.org, Date accessed: June 3, 2009.

6. McLaughin CC, Wu XC, Jemal A et al. Incidence of noncutaneous melanomas in the US, Cancer 2005;103:1000.

7. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Comission on Cancer and the American Cancer Society. Cancer 1998;83:1664.

8. Wong JH, Cagle LA, Storm FK, Morton DL. Natural history of surgically treated mucosal melanoma. Am J Surg 1987;154:54

9. Ulger AF, Sen E, Erekul S, Gonullu U. Malignant melanoma of the lung:is it easy to determine its origin? Arch Bronconeumol 2005;41:102-104.

10. Kundranda MN, Clark CT, Chaundry AA et al. Primary malignant melanoma of the lung: a case report and review of the literature. Clin. Lung Cancer 2006;7:279-281.

11. Reddy VS, Mykytenko J, Giltmann LI et al. Primary malignant melanoma of the lung: review of literature and report of a case. Am Surg 2007;73:287-289.

12. Maeda R, Isowa N, Onuma H et al. Primary malignant melanoma of the lung with rapid progression. Gen Thorac Cardiovasc Surg 2009;57:671-674.

13. Kirkwood JM, Strawderman MH, Ernstoff MS et al. Interferona-2b adjuvant therapy of high risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group trial EST 1684. J Clin Oncol 1996;14:7.

14. Atkins MB. The role of cytotoxic chemotherapeutic agents either alone or in combination with biological response modifiers. In: Molecular Diagnosis, Prevention and Therapy of Melanoma. Kirkwood JK (Ed), Marcel Dekker, New York 1997. p.219.

15. Bajetta E, Del Vecchio M, Bernard-Marty C et al. Metastatic melanoma: chemotherapy. Semin Oncol 2002;29:427-445.

16. Kim KB, Sanguino AM, Hodges C et al. Biochemotherapy in patients with metastatic anorectal mucosal melanoma. Cancer 2004;100:1478.

17. Bastiaannet E, Beukema JC, Hoekstra HJ. Radiation therapy following lymph node dissection in melanoma patients: treatment, outcome and complications. Cancer Treat Rev 2005;31:18-26.

18. Tang H, Huang H, Xiu Q, Shi Z. Isolated splenic metastasis from lung cancer: ringleader of continuous fever. Eur Respir Rev 2010;19:117,253-256.

19. Ost D, Joseph C, Sogoloff H, Menezes G. Primary Malignant melanoma: case report and literature review. Mayo Clin Proc 1999;74:62-6.

20. Klein B, Stein M, Kuten A, et al. Splenomegaly and solitary spleen metastasis in solid tumors. Cancer 1987;60:100-2.

21. Trindade MR, Blaya R, Trindade EN. Melanoma metastasis to the spleen: Laparoscopic approach. J Minim Access Surg 2009;5:17-19.
Keywords Cutaneous and non-cutaneous melanomas, primary malignant melanoma of the lung (PMML), diagnostic criteria, surgery, adjuvant chemotherapy and radiotherapy, splenic metastases
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